Metabolic Precursor of Cholesterol Causes Formation of Chained Aggregates of Liquid-Ordered Domains

Langmuir : the ACS Journal of Surfaces and Colloids
Galya StanevaSergey A Akimov

Abstract

7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between rafts and formation of the so-called signaling platforms. In model membranes, cholesterol-based ordered domains usually merge upon contact. According to our experimental data, ordered domains in the model systems where cholesterol is substituted for 7-dehydrocholesterol never merge on the time scale of the experiment, but clusterize into necklace-like aggregates. We attribute such different dynamical behavior to altered properties of the domain boundary. In the framework of thickness mismatch model, we analyzed changes of interaction energy profiles of two approaching domains caused by substitution of cholesterol by 7-dehydrocholesterol. The energy barrier for domain merger is shown to increase notably, with simultaneous appearance of another distinct local energy minimum. Such energy profile is in perfect qualitative agreement with the experimental observations. The observed change of doma...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L RubensteinH M McConnell
Jun 5, 1997·Nature·K Simons, E Ikonen
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
Feb 27, 2001·Biophysical Journal·C DietrichE Gratton
Mar 27, 2001·Current Opinion in Lipidology·J M Dietschy, S D Turley
Mar 30, 2001·The Journal of Biological Chemistry·H GrassmeE Gulbins
Dec 26, 2001·Biophysical Journal·Michael R BrzustowiczStephen R Wassall
Jan 25, 2003·Annual Review of Biophysics and Biomolecular Structure·Michael Edidin
Sep 26, 2003·Biophysical Journal·Rodrigo F M de AlmeidaManuel Prieto
Nov 16, 2004·Biophysical Journal·Peter I KuzminFredric S Cohen
May 17, 2005·Biophysical Journal·T BaumgartJ T Jenkins
Jul 20, 2005·Journal of Computational Chemistry·Zoe CourniaG Matthias Ullmann
Jul 27, 2005·Biochimica Et Biophysica Acta·Sarah L Veatch, Sarah L Keller
Oct 7, 2005·Clinical Genetics·H Yu, S B Patel
Apr 19, 2006·The Journal of Experimental Medicine·Martina KovarovaJuan Rivera
May 12, 2007·Biochemical and Biophysical Research Communications·Pushpendra SinghAmitabha Chattopadhyay
Sep 13, 2007·The Journal of Biological Chemistry·Ana J García-SáezPetra Schwille
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Feb 21, 2008·European Journal of Human Genetics : EJHG·Forbes D Porter
Jul 23, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sergey A AkimovFredric S Cohen
Nov 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·H Jelger Risselada, Siewert J Marrink
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jianjun PanJohn F Nagle
Dec 16, 2010·Biophysical Journal·Lars V Schäfer, Siewert J Marrink
Apr 9, 2011·Journal of the American Chemical Society·Jason D Perlmutter, Jonathan N Sachs
Jul 23, 2011·Expert Reviews in Molecular Medicine·Andrea E DeBarberRobert D Steiner
Mar 29, 2014·Soft Matter·Benjamin KollmitzerGeorg Pabst
Feb 19, 2015·Biophysical Journal·Peter HeftbergerGeorg Pabst
Mar 4, 2015·Expert Opinion on Orphan Drugs·Simona E BianconiForbes D Porter
Sep 5, 2015·Physical Review Letters·Timur R GalimzyanovSergey A Akimov

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Citations

Mar 23, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·T R GalimzyanovO V Batishchev
Dec 7, 2017·International Journal of Molecular Sciences·Rodion J MolotkovskySergey A Akimov
Nov 16, 2019·Biomolecules·Rodion J MolotkovskySergey A Akimov
Jan 23, 2020·Physical Review. E·Boris KheyfetsTimur Galimzyanov
Aug 6, 2020·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Dec 2, 2020·Membranes·Oleg V KondrashovSergey A Akimov
Nov 21, 2020·Physical Review. E·Konstantin V PiniginTimur R Galimzyanov
Oct 30, 2021·Biophysical Journal·Oleg V KondrashovSergey A Akimov

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