PMID: 6413656Nov 1, 1983Paper

Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex

Journal of Neurochemistry
N R SimsA N Davison

Abstract

Samples of neocortex removed at diagnostic craniotomy from patients with Alzheimer's disease and incubated in vitro showed an increased production of 14CO2 from [U-14C]glucose compared with neurosurgical controls. This was a feature of incubations in the presence of both 5 mM K+ (142% control) and 31 mM K+ (126%). Specific labelling of the amino acid pool was unaltered, suggesting that the apparent increase of CO2 production was not merely a reflection of changes in dilution of the radiolabel from glucose. The content of adenine nucleotides was significantly less than control values in the tissue from patients with Alzheimer's disease after in vitro incubations but the adenylate energy charge was unchanged, indicating that normal energy metabolism was not grossly impaired in these preparations.

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Citations

Jun 1, 1990·Annals of Neurology·N R Sims
Mar 1, 1987·Journal of the Neurological Sciences·P T FrancisJ S Snowden
Nov 1, 1992·Archives of Gerontology and Geriatrics·U SeninM Fioravanti
Mar 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Hoyer
Apr 1, 1996·Progress in Neurobiology·J G Greene, J T Greenamyre
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Jun 1, 1993·Free Radical Biology & Medicine·S C Bondy, C P LeBel
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Sep 5, 1985·The New England Journal of Medicine·N R SimsJ P Blass
Dec 4, 2012·International Journal of Molecular Sciences·Kaushik ShahThomas Abbruscato
Jan 1, 1987·Journal of Neurochemistry·A M PalmerD M Bowen
Sep 25, 2003·Neurological Research·John P Blass
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A DingS Hoyer
Oct 21, 2006·Journal of Neural Transmission·K Maurer, S Hoyer
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Jan 1, 1984·Neurochemical Pathology·J P Blass, A Zemcov

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