Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway.

Biochimica Et Biophysica Acta
M ClaeysD H Nugteren


Porcine neutrophilic leukocytes were found to contain a lipoxygenase which converted linoleic acid into 13-hydroxy-9,11-octadecadienoic acid (n-6 specificity), arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid (n - 9 specificity) and 5-hydroxy-6,8,11,14-eicosatetraenoic acid into 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid. This lipoxygenase was partially purified and it appeared that its substrate specificity and other properties were quite different from the 12-lipoxygenase of blood platelets. Incubations of intact or broken porcine leukocytes with added linoleic acid revealed the formation of not only 13-hydroxy-9,11-octadecadienoic acid but also of substantial amounts of epoxyhydroxy and trihydroxy isomers. These products from linoleate, collectively described by the name 'octadecanoids' were characterized in detail by a combination of chemical, chromatographic and mass spectrometric techniques. The phospholipids of porcine leukocytes contain more than twice as much linoleate than arachidonate (22 vs. 8%). In accordance with this fatty acid composition we found that in the stimulated neutrophil the endogenous production of octadecanoids often surpassed that of the eicosanoids. Lipoxygenation of endogenousl...Continue Reading


May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P Borgeat, B Samuelsson
Feb 20, 1975·Biochimica Et Biophysica Acta·D H Nugteren
May 17, 1985·Biochimica Et Biophysica Acta·D H NugterenU M Houtsmuller
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L MaasJ A Oates
Jun 1, 1983·Biochemical Pharmacology·F OeschH R Glatt
May 15, 1980·Analytical Biochemistry·J M BoeynaemsW C Hubbard
Sep 1, 1970·Plant Physiology·D C Zimmerman, B A Vick
Oct 1, 1981·Plant Physiology·E C LulaiD C Zimmerman
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin H CohenRichard Pazdur
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Leonardus M I KoharudinAngela M Gronenborn

❮ Previous
Next ❯


Apr 1, 1990·Agents and Actions·D van Heuven-NolsenF P Nijkamp
Sep 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·G A CherednichenkoS A Ogiĭ
Dec 1, 1992·Prostaglandins·G BioqueE Gelpi
Jan 1, 1991·Free Radical Biology & Medicine·S Yamamoto
Dec 5, 1998·Free Radical Biology & Medicine·H IwaseM Kobayashi
May 7, 2003·Trends in Cardiovascular Medicine·Yeshao WenJerry Nadler
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T IzumiB Samuelsson
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T YoshimotoT Tanabe
Jan 1, 1990·British Journal of Clinical Pharmacology·D van Heuven-NolsenF P Nijkamp
Sep 1, 1989·American Journal of Respiratory Cell and Molecular Biology·J R HansbroughM J Holtzman
Jul 1, 1995·The Journal of Clinical Investigation·V A FolcikM K Cathcart
Apr 1, 1992·Journal of Neurochemistry·M NishiyamaT Kirino
Sep 1, 1994·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A N Orekhov, A G Panossian
May 22, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yuki KawakamiYoshitaka Takahashi
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Yamamoto
Jul 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G BioqueE Gelpí
Sep 7, 2005·Biochemical and Biophysical Research Communications·Hiroo KawajiriTanihiro Yoshimoto
Nov 30, 1987·Biochemical and Biophysical Research Communications·P WalstraJ F Vliegenthart
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KawadaS Yamamoto
Jan 1, 1995·Rapid Communications in Mass Spectrometry : RCM·G BioqueE Gelpí
Dec 1, 1988·Hypertension·R J GryglewskiJ R Vane
Oct 28, 2015·Journal of the American Heart Association·Sandrine Ellero-SimatosUNKNOWN Pharmacometabolomics Research Network
Mar 12, 2016·The European Respiratory Journal·David BalgomaCraig E Wheelock
Jan 10, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·David FuchsCraig E Wheelock
Apr 1, 1994·The American Journal of Physiology·L L StollA A Spector

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.