Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1H magnetic resonance spectroscopy

NMR in Biomedicine
Marinette van der GraafArend Heerschap

Abstract

Localized in vivo 1H magnetic resonance spectroscopy (MRS) was used to investigate metabolite levels in the brain of adult Zucker Diabetic Fatty (ZDF) rats, an animal model for type 2 diabetes mellitus. This study focussed on the hippocampus, assumed to be one of the main brain areas affected by this disease. Together with an almost 5-fold increase in blood glucose concentration measured by glucose oxidation, significant increases were found in the hippocampal concentrations of glucose (4.93 vs 1.66 mM p < 0.001), myo-inositol (6.52 vs 4.30 mM; p < 0.05), and total creatine (12.71 vs 10.50 mM; p < 0.05) in ZDF rats (n = 5) compared with littermates (n = 5). Although no obvious alterations were detected in the hippocampal levels of other metabolites, including NAA + NAAG and choline-containing compounds in the ZDF rats, the increase in Glc and Ins levels is in line with elevated brain tissue contents of these metabolites in patients with diabetes mellitus.

Citations

Dec 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Olusola AjiloreAnand Kumar
Jun 18, 2011·American Journal of Respiratory and Critical Care Medicine·Natalie J SerkovaKathleen A Stringer
Dec 16, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Liangcai ZhaoDonghai Lin
Dec 4, 2012·International Journal of Molecular Sciences·Kaushik ShahThomas Abbruscato
Apr 17, 2010·ASN Neuro·Gautam K GandhiGerald A Dienel
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias K AuerPeter Gass
Nov 28, 2015·Neurochemical Research·Erica B SherryIn-Young Choi
Dec 11, 2008·Pediatric Diabetes·John I MaloneDavid M Diamond
Oct 2, 2015·Aging and Disease·João M N Duarte
Jan 10, 2012·NeuroImage·João M N DuarteRolf Gruetter
Jun 22, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lili SongYanjun Zhang
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qian GuoLirong Wu
Jun 7, 2006·Blood Purification·Marco RighettiGianmichele Ferrario
Jul 20, 2007·European Journal of Clinical Investigation·B Kestenbaum, V Belozeroff
Oct 24, 2007·Journal of Internal Medicine·C L HewitsonA A Mangoni
May 12, 2010·American Journal of Physiology. Cell Physiology·Asya MakhroAnna Bogdanova
Aug 14, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell
Dec 25, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Meng-Ya ZhangYao-Wu Liu
Jun 4, 2019·Neurotoxicity Research·Pascale BelenguerGustavo C Ferreira
Feb 27, 2020·Antioxidants & Redox Signaling·Cristina Carvalho, Susana Cardoso
Dec 3, 2020·Nutrients·Nicole L Stott, Joseph S Marino
May 1, 2021·Reviews in Endocrine & Metabolic Disorders·Medha Sharma, Chinmoy Sankar Dey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
A GeisslerB Zietz
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Olusola AjiloreAnand Kumar
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
I TkácRolf Gruetter
© 2021 Meta ULC. All rights reserved