PMID: 518169Dec 1, 1979Paper

Metabolic profiles of thermal trauma

Annals of Surgery
F J VolenecL J Humphrey

Abstract

The study was designed to establish where significant correlations exist in a variety of metabolic substrates and hormone mediators in patients sustaining thermal injury. The factors studied were insulin, human growth hormone, cortisol, glucagon, free fatty acid, triglyceride and glucose. Incorporated into this design was an evaluation of the impact of quantitated severity of injury upon these correlations. In patients sustaining a low severity of injury (Probability of death (p = 2.2 to 33.9) there appeared a loss of glucose regulation in conjunction with insulin resistance without significant interplay of other factors studied. In contrast, patients sustaining high severity injury (p = 46.9 to 100) evidenced correlations between glucagon and glucose (negative), cortisol and free fatty acid indicating a significant role of hyperglucagonemia in these patients. A discriminant function analysis was employed to incorporate all significant variables into a probability model. Only insulin, glucose and glucagon appeared in the optimal classification equation.

References

Apr 1, 1978·The Journal of Trauma·T L WachtelL W Shuck
May 1, 1977·The Journal of Trauma·J TurinskyT Chesnut
Sep 1, 1977·The Journal of Trauma·J M ShuckD S Schade
Apr 26, 1975·British Medical Journal·C I OrtonJ Clarke
Mar 11, 1976·Annals of Surgery·D W WilmoreB A Pruitt
Apr 1, 1973·American Journal of Surgery·J M HiebertR H Egdahl
May 1, 1974·The Journal of Trauma·F E GumpJ M Kinney
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Apr 1, 1957·Annals of Surgery·M GOODALLB W HAYNES

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Citations

Sep 23, 2003·The Journal of Burn Care & Rehabilitation·Theresa MayesGlenn D Warden
Jun 1, 1996·The Journal of Trauma·E A CarterA J Fischman
Jul 1, 1982·Annals of Neurology·D MohnotJ W Benton
Aug 17, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Amy K WiseKeith R Miller

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