Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

Metabolomics : Official Journal of the Metabolomic Society
Roel Van AsscheUte Roessner

Abstract

Despite decades of research, no early-onset biomarkers are currently available for Alzheimer's disease, a cureless neurodegenerative disease afflicting millions worldwide. In this study, transgenic Caenorhabditis elegans were used to investigate changes in the metabolome after induced expression of amyloid-β. GC- and LC-MS-based platforms determined a total of 157 differential features. Some of these were identified using in-house (GC-MS) or public libraries (LC-MS), revealing changes in allantoin, cystathionine and tyrosine levels. Since C. elegans is far better suited to metabolomics studies than most other model systems, the accordance of these findings with vertebrate literature is promising and argues for further use of C. elegans as a model of human pathology in the study of AD.

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Citations

Apr 4, 2015·Journal of Molecular Biology·Roel Van AsscheLiesbet Temmerman
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Hongmin XuShuye Liu
Jan 5, 2018·Journal of the American Society for Mass Spectrometry·Sven Van BaelLiesbet Temmerman
Jul 25, 2019·Laboratory Medicine·Wang Gu, Zhong Tong
Jan 28, 2020·Nutrition and Healthy Aging·Arjun Sengupta, Aalim M Weljie
Aug 24, 2017·Journal of Negative Results in Biomedicine·Roel Van AsscheLiesbet Temmerman
Nov 17, 2020·Frontiers in Molecular Biosciences·Yiqu CaoPeng Jin
Dec 3, 2020·Brain Sciences·Edyta SochaEmilia Daghir-Wojtkowiak
Feb 19, 2021·Molecular Omics·Balasubramanian Chellammal MuthubharathiKrishnaswamy Balamurugan
Aug 20, 2020·Journal of Pharmaceutical and Biomedical Analysis·Özge Cansın ZekiEmirhan Nemutlu
Nov 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marwa ZafarullahFlora Tassone

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Methods Mentioned

BETA
imaging techniques
nuclear magnetic resonance
transgenic
metabolomics
PCA

Software Mentioned

Agilent MassHunter Workstation
R package metabolomics
MZmine
CAMERA

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