Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure

Aquatic Toxicology
Ming-Hui LiJun-Song Wang

Abstract

Glyphosate is an efficient herbicide widely used worldwide. However, its toxicity to non-targeted organisms has not been fully elucidated. In this study, the toxicity of glyphosate-based herbicide was evaluated on goldfish (Carassius auratus) after long-term exposure. Tissues of brains, kidneys and livers were collected and submitted to NMR-based metabolomics analysis and histopathological inspection. Plasma was collected and the blood biochemical indexes of AST, ALT, BUN, CRE, LDH, SOD, GSH-Px, GR and MDA were measured. Long-term glyphosate exposure caused disorders of blood biochemical indexes and renal tissue injury in goldfish. Metabolomics analysis combined with correlation network analysis uncovered significant perturbations in oxidative stress, energy metabolism, amino acids metabolism and nucleosides metabolism in glyphosate dosed fish, which provide new clues to the toxicity of glyphosate. This integrated metabolomics approach showed its applicability in discovering the toxic mechanisms of pesticides, which provided new strategy for the assessment of the environmental risk of herbicides to non-target organisms.

Citations

Jan 10, 2018·Environmental Science and Pollution Research International·Emma FiorinoCaterina Faggio
Jul 1, 2020·Scientific Reports·Diego E VázquezWalter M Farina
Oct 15, 2020·Scientific Reports·Yuri P TsentalovichIliya M Odud
Mar 24, 2020·Environmental Pollution·Islam Md MeftaulMallavarapu Megharaj
Mar 20, 2021·Analytica Chimica Acta·M Hernández-MesaG Dervilly
Mar 23, 2021·The Science of the Total Environment·Donna A GlinskiW Matthew Henderson
Sep 30, 2021·Nature Reviews. Nephrology·Adebowale A AdeyemoCharles N Rotimi
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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