Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness.

Journal of Cachexia, Sarcopenia and Muscle
Paul R KempMark Griffiths

Abstract

Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little, and is likely to be accompanied by marked changes in circulating metabolites and proteins. Determining these changes may help understand the variability and identify novel therapeutic approaches or markers of muscle wasting. To determine the association between muscle loss and circulating metabolites, we studied 20 male patients (median age, 70.5, interquartile range, 62.5-75) undergoing aortic surgery. Muscle mass was determined before and 7 days after surgery and blood samples were taken before surgery, and 1, 3, and 7 days after surgery. The circulating metabolome and proteome were determined using commercial services (Metabolon and SomaLogic). Ten patients lost more than 10% of the cross-sectional area of the rectus femoris (RFCSA ) and were defined as wasting. Metabolomic analysis showed that 557 circulating metabolites were altered following surgery (q < 0.05) in the whole cohort and 104 differed between wasting and non-wasting patients (q < 0.05). Weighted genome co-expression network analysis,...Continue Reading

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Citations

Nov 21, 2020·Mechanisms of Ageing and Development·Ted Kheng Siang NgDavid Bruce Matchar

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
PCA
biopsy
coronary artery bypass
ELISA
pharmacotherapy

Software Mentioned

Metabolon
R package weighted genome co ‐ expression network analysis ( W...
WGCNA
Metaboanalyst
SOMAscan®
R package WGCNA
SomaLogic

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