Metabolic proteomics of the liver and mammary gland during lactation

Journal of Proteomics
Pisana RawsonT William Jordan

Abstract

The liver and the mammary gland have complementary metabolic roles during lactation. Glucose synthesized by the liver is released into the circulation and is taken up by the mammary gland where major metabolic products of glucose include milk sugar (lactose) and the glycerol backbone of milk fat (triglycerides). Hepatic synthesis of glucose is often accompanied by β-oxidation in that organ to provide energy for glucose synthesis, while mammary gland synthesizes rather than oxidizes fat during lactation. We have therefore compared enzyme abundances between the liver and mammary gland of lactating Friesian cows where metabolic output is well established. Quantitative differences in protein amount were assessed using two-dimensional differential in-gel electrophoresis. As predicted, the abundances of enzymes catalysing gluconeogenesis and β-oxidation were greatest in the liver, and enzyme abundances in mammary tissue were consistent with fat synthesis rather than β-oxidation.

References

Jan 1, 1992·Annual Review of Physiology·S J Pilkis, D K Granner
Oct 8, 1998·Advances in Enzyme Regulation·S Thomas, D A Fell
Nov 16, 2006·Physiological Genomics·Michael C RudolphMargaret C Neville
Mar 8, 2008·Journal of Proteome Research·Lifeng PengT William Jordan
Apr 3, 2008·Proteomics·Amanda J BeddekT William Jordan
Aug 2, 2008·BMC Genomics·Massimo Bionaz, Juan J Loor
Dec 21, 2010·IUBMB Life·Jörg R AschenbachGregory B Penner
Mar 2, 2011·Infection and Immunity·Bhagyashree ManivannanAnne Camille La Flamme

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Citations

Aug 4, 2015·Veterinary Microbiology·A I KatsafadouG C Fthenakis
May 30, 2015·Journal of Proteomics·Shveta BathlaAshok K Mohanty
Oct 1, 2013·Journal of Proteomics·Ana M FerreiraAndré M Almeida
Dec 25, 2017·Functional & Integrative Genomics·Wen-Ting DaiHong-Yun Liu
Oct 27, 2015·Proteomes·Jonathan C DunneT William Jordan
Sep 1, 2019·Pathogens·Angeliki I KatsafadouGeorge C Fthenakis
Aug 17, 2020·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Courtney B BettsPepper J Schedin
Dec 16, 2016·Cancer Discovery·Erica T GoddardPepper Schedin

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