PMID: 3384030Jan 1, 1988Paper

Metabolic rates in genetically based long lived strains of Drosophila

Experimental Gerontology
R ArkingR Pretzlaff

Abstract

The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; however, the higher longevity of the L strain relative to the R strain is not affected by these treatments. Therefore, the genetic factors unique to the L strain do not affect the same processes affected by the temperature treatments. A second set of experiments detected a linear relationship between the MDMR (mean daily metabolic rate) and the ambient adult temperature. However, at each temperature, the MDMR of either strain was statistically equivalent; a finding which demonstrates that an increased life span depends on something other than conservation of calories. A third set of experiments looked at the metabolic efficiency of the two strains and were not able to detect any statistically significant differences. The two strains appear to expend approximately equivalent numbers of calories per day in an approximately equivalent manner. These data are interpreted in the context both of a previously postulated ge...Continue Reading

References

Sep 1, 1976·Mechanisms of Ageing and Development·J MiquelH Atlan
Mar 7, 1986·Science·J E FlemingK G Bensch
Jan 1, 1986·Experimental Gerontology·R S Sohal, J H Runnels
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Citations

Jun 1, 1991·Aging : Clinical and Experimental Research·E J Masoro, R J McCarter
Oct 1, 2001·Journal of the American Aging Association·S A Buck, R Arking
Jul 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·E Le BourgP Bullens
Jan 1, 1996·Experimental Gerontology·R J Shmookler Reis, R H Ebert
Feb 10, 1999·Experimental Gerontology·S M Jazwinski
Jun 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Vassily N NovoseltsevAnatoli I Yashin
Jul 30, 2002·Evolution; International Journal of Organic Evolution·V N NovoseltsevA I Yashin
Jan 1, 1988·Experimental Aging Research·R Arking
Oct 14, 2005·Biological Reviews of the Cambridge Philosophical Society·Peter A Parsons
Mar 11, 2005·Journal of Theoretical Biology·A J Hulbert
Jan 19, 2011·Journal of Insect Physiology·Dimitri A SkandalisGlenn J Tattersall
Aug 1, 1989·Journal of the American Geriatrics Society·R Arking, S P Dudas
Jul 30, 2004·Biochimica Et Biophysica Acta·Eric Dufour, Nils-Göran Larsson
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Hakan AyA Gregory Sorensen
Sep 2, 2003·Journal of Applied Physiology·Wayne A van VoorhiesJames W Curtsinger
Oct 12, 2007·Physiological Reviews·A J HulbertW A Buttemer
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Venkatesh Nagarajan-RadhaDamian K Dowling
Jan 5, 1999·Genome Research·J C JiangS M Jazwinski
Jan 25, 2002·Annals of the New York Academy of Sciences·R Arking
Sep 1, 1992·The American Journal of Physiology·R J McCarter, J Palmer
Jul 5, 1996·Science·S M Jazwinski

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