Metabolic regulation of suppressive myeloid cells in cancer

Cytokine & Growth Factor Reviews
Antonio SicaChiara Porta

Abstract

Cancer cells rewire their metabolism to promote growth, survival, proliferation and long-term maintenance. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate, which is observed even in the presence of completely functioning mitochondria. This effect is known as the 'Warburg Effect' and its intensive investigation in the last decade has partially established either its causes or its functions. It is now emerging that a major side effect of the Warburg Effect is immunosuppression, which limits the immunogenicity of cancer cells and therefore restricts the therapeutic efficacy of anticancer immunotherapy. Here we discuss how the metabolic communication between cancer and infiltrating myeloid cells contributes to cancer immune evasion and how the understanding of these mechanisms may improve current immunotherapies.

Citations

Jul 10, 2018·Carcinogenesis·Chiara PortaAntonio Sica
Mar 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Maria Teresa Di MartinoCarlo Leonetti
Jun 30, 2019·Pharmaceuticals·Stefania RecalcatiGaetano Cairo
Jan 9, 2019·Frontiers in Cell and Developmental Biology·Je Lin SieowSiew Cheng Wong
Jan 25, 2019·Oncology Letters·Xin ChenJun Li
Mar 29, 2019·Redox Biology·Sin Yee GunSiew Cheng Wong
Aug 22, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Miguel Ángel Souto-Del BosqueGerardo Del Carmen Palacios-Saucedo
Dec 24, 2020·Blood Reviews·Binyan XuYuhua Li

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