Metabolic response to optic centers to visual stimuli in the albino rat: anatomical and physiological considerations

The Journal of Comparative Neurology
A W Toga, R C Collins

Abstract

The functional organization of the visual system was studied in the albino rat. Metabolic differences were measured using the 14-C-2-deoxyglucose (DG) autoradiographic technique during visual stimulation of one entire retina in unrestrained animals. All optic centers responded to changes in light intensity but to different degrees. The greatest change occurred in the superior colliculus, less in the lateral geniculate, and considerably less in second-order sites such as layer IV of visual cortex. These optic centers responded in particular to on/off stimuli, but showed no incremental change during pattern reversal or movement of orientation stimuli. Both the superior colliculus and lateral geniculate increased their metabolic rate as the frequency of stimulation increased, but the magnitude was twice as great in the colliculus. The histological pattern of metabolic change in the visual system was not homogenous. In the superior colliculus glucose utilization increased only in stratum griseum superficiale and was greatest in visuotopic regions representing the peripheral portions of the visual field. Similarly, in the lateral geniculate, only the dorsal nucleus showed an increased response to greater stimulus frequencies. Second...Continue Reading

References

Jul 28, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D H Hubel, T N Wiesel
Jan 1, 1979·Annual Review of Neuroscience·R W Rodieck
Aug 1, 1979·Annals of Neurology·R C Collins, T V Caston
Feb 1, 1978·The Journal of Comparative Neurology·D H HubelM P Stryker
Jul 15, 1979·The Journal of Comparative Neurology·F Scalia, V Arango
Nov 1, 1977·Physiology & Behavior·C R Legg, A Cowey
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C KennedyL Sokoloff
Nov 1, 1976·The Journal of Physiology·S Hochstein, R M Shapley
Jun 1, 1975·The Journal of Physiology·B G ClelandH Wässle
Sep 1, 1975·The Journal of Comparative Neurology·J P Kelly, C D Gilbert
Jun 27, 1975·Brain Research·B G ClelandW R Levick
Sep 1, 1972·The Journal of Comparative Neurology·R Y Moore, N J Lenn
Jan 1, 1967·Experimental Neurology·R E Walley
Jun 1, 1972·The Journal of Comparative Neurology·F Scalia
Jul 1, 1974·Journal of Neurophysiology·Y Fukuda, J Stone
Mar 1, 1968·Journal of Neurophysiology·V M MonteroR E Beitel
Aug 1, 1966·The Journal of Comparative Neurology·R SiminoffL Kruger
Nov 1, 1966·The Journal of Physiology·W Burke, A Jervie Sefton
Aug 1, 1967·The Journal of Comparative Neurology·R SimonoffL Kruger
Jan 1, 1980·Annual Review of Neuroscience·R H Wurtz, J E Albano
Oct 1, 1960·The Journal of Comparative Neurology·W R HAYHOWA JERVIE
Feb 1, 1961·The Journal of Physiology·D H HUBEL, T N WIESEL
Nov 1, 1951·The Biochemical Journal·H McILWAINJ D CHESHIRE
Apr 1, 1946·The Journal of Comparative Neurology·W J S KRIEG

❮ Previous
Next ❯

Citations

Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T WatanabeJ Frahm
Nov 28, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·M L Soto-MontenegroM Desco
Jun 3, 1985·Brain Research·H Rowley, R C Collins
May 1, 1995·Journal of Neuroscience Methods·A WreeT Beck
Feb 1, 1987·Behavioural Brain Research·B Kolb, J Walkey
Oct 1, 1995·Behavioural Brain Research·W F McDanielH M Ledesma
May 1, 1989·Computer Methods and Programs in Biomedicine·D R Gitelman, A W Toga
Jul 1, 1994·Brain Research. Cognitive Brain Research·J R BinderJ S Hyde
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P YarowskyL Sokoloff
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N SadatoM Hallett
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M S VafaeeA Gjedde
Jun 9, 1998·Annals of the New York Academy of Sciences·R C Collins
Jun 7, 2005·Okajimas Folia Anatomica Japonica·Daniel GonzalezYoshiki Takeuchi
Jan 1, 1994·Human Brain Mapping·B Horwitz, O Sporns
Nov 1, 1981·Physiology & Behavior·A W Toga, R C Collins
Aug 8, 1994·The Journal of Comparative Neurology·M HerbinH M Cooper
Aug 30, 2007·Journal of Neurochemistry·Gerald A DienelNancy F Cruz
Mar 26, 1986·Brain Research·T T SoncrantS I Rapoport
Feb 11, 2003·IEEE Transactions on Medical Imaging·Arthur W Toga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.