Metabolic responses to change in disease activity during tumor necrosis factor inhibition in patients with rheumatoid arthritis

Journal of Proteome Research
Rasmus MadsenJohan Trygg

Abstract

Assessment of disease activity in patients with rheumatoid arthritis (RA) is of importance in the evaluation of treatment. The most important measure of disease activity is the Disease Activity Score counted in 28 joints (DAS28). In this study, we evaluated whether metabolic profiling could complement current measures of disease activity. Fifty-six patients, in two separate studies, were followed for two years after commencing anti-TNF therapy. DAS28 was assessed, and metabolic profiles were recorded at defined time points. Correlations between metabolic profile and DAS28 scores were analyzed using multivariate statistics. The metabolic responses to lowering DAS28 scores varied in different patients but could predict DAS28 scores at the individual and subgroup level models. The erythrocyte sedimentation rate (ESR) component in DAS28 was most correlated to the metabolite data, pointing to inflammation as the primary effect driving metabolic profile changes. Patients with RA had differing metabolic response to changes in DAS28 following anti-TNF therapy. This suggests that discovery of new metabolic biomarkers for disease activity will derive from studies at the individual and subgroup level. Increased inflammation, measured as E...Continue Reading

References

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Jan 28, 2010·Analytica Chimica Acta·Rasmus MadsenJohan Trygg
Aug 13, 2010·Journal of Proteome Research·Michael B LauridsenClaus Cornett
Feb 10, 2011·Arthritis Research & Therapy·Rasmus K MadsenJohan Trygg

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Citations

Jan 25, 2016·Rheumatology International·Izabella SurowiecRoald Omdal
May 10, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Andres GomezVeena Taneja
May 9, 2016·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiCatherine A Thornton
Dec 6, 2016·Clinical Genetics·Xiaoxia ZuoHonglin Zhu
Dec 14, 2017·Metabolomics : Official Journal of the Metabolomic Society·Tae Hwan ShinChang-Hee Suh

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