Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery.

Scientific Reports
J Romeo Villarreal-CalderonLeticia Elizondo-Montemayor

Abstract

Bariatric and metabolic surgery has shown to promote weight loss and reduce systemic inflammation. However, the sequence and timing of events regarding metabolic improvement and inflammation resolution has been rarely explored. Furthermore, data on inflammatory markers of Th17 and Th1 cell responses after bariatric surgery is scarce. We conducted a prospective study in subjects with obesity that underwent bariatric and metabolic surgery, with follow-ups at 3 and 6 months. Anthropometric and metabolic markers such as insulin levels, HOMA-IR, and lipid parameters declined significantly 3 months after surgery; while hs-CRP, TNF-α, IL-1β, IL-6, and IL-8 serum concentrations decreased 6 months after the procedure. Concentrations of Th1 signature and driver cytokines, particularly IFN-γ, IL-12, and IL-18, and of Th17 driver IL-23 also decreased significantly after 6 months. Significant positive correlations between triglyceride levels and hs-CRP, IL-1β, and IFN-γ concentrations, and between Apo B and IFN-γ levels were observed 6 months after bariatric and metabolic surgery. In addition, BMI was associated with hs-CRP and TNF-α concentrations. Fat mass correlated with hs-CRP, TNF-α, and IL-12. Analysis of the temporality of metabolic ...Continue Reading

References

Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Mar 3, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D AronsonY Levy
Aug 24, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Stanley M ZagorskiMathew H Chung
Dec 2, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Joshua G LeichmanHeinrich Taegtmeyer
Jul 29, 2008·Circulation Research·Viviane Zorzanelli RochaPeter Libby
Apr 21, 2009·The American Journal of Medicine·Michael A TrakhtenbroitHeinrich Taegtmeyer
Apr 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·N B JørgensenJ J Holst
May 9, 2012·Cell Metabolism·Christopher K Glass, Jerrold M Olefsky
Jun 6, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D P AnderssonP Arner
Apr 26, 2014·World Journal of Diabetes·Qiang SunFeng Gao
Oct 21, 2014·Metabolic Syndrome and Related Disorders·Torunn Kristin NestvoldKnut Tore Lappegård
Dec 3, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Akhila MallipedhiJeffrey W Stephens
Oct 31, 2015·Surgical Endoscopy·Valerie G SamsNaima Moustaid-Moussa
Jan 21, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y RitzeS C Bischoff
May 22, 2016·Bioinformatics·Zuguang GuMatthias Schlesner
Jul 28, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Samar HafidaBarbara S Nikolajczyk
Aug 31, 2016·Diabetes Care·Amalia GastaldelliGeltrude Mingrone
Oct 4, 2016·Cell Metabolism·Kevin ManAjay Chawla
Dec 18, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Roberta SchmatzVera Maria Morsch
Feb 10, 2017·Nature·Gökhan S Hotamisligil
Mar 4, 2017·Endokrynologia Polska·María L Fernández-SotoFernándo Escobar-Jiménez
Mar 21, 2017·Canadian Journal of Diabetes·Thomas Grenier-LaroucheAndré C Carpentier
Mar 24, 2018·JAMA : the Journal of the American Medical Association·Craig M HalesCynthia L Ogden
Sep 1, 2018·Diabetes & Metabolic Syndrome·Firass AbiadGhina Ghazeeri

❮ Previous
Next ❯

Software Mentioned

Tidyverse
Complex Heatmaps
ComplexHeatmap
R
Hmisc

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.