Apr 18, 2016

Metabolic signatures of birth weight in 18288 adolescents and adults

BioRxiv : the Preprint Server for Biology
Peter WürtzKirsi Auro


Background: Lower birth weight is associated with increased susceptibility to cardiometabolic diseases in adulthood, but the underlying molecular pathways are incompletely understood. We examined associations of birth weight with a comprehensive metabolic profile measured in adolescents and adults. Methods: High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used to quantify 87 circulating metabolic measures in seven cohorts from Finland and the United Kingdom comprising altogether 18 288 individuals (mean age 26 years, range 15-75). Metabolic associations with birth weight were assessed by linear regression models adjusted for sex, gestational age, and age at blood sampling. The metabolic associations with birth weight were compared to the corresponding associations with adult body mass index (BMI). Results: Lower birth weight was adversely associated with cardiometabolic biomarkers, including lipoprotein subclasses, fatty acids, amino acids, and markers of inflammation and impaired liver function (P<0.0015 for 46 measures). Associations were consistent across cohorts with different ages at metabolic profiling, but the magnitudes were weak. The pattern of metabolic deviations associated with low...Continue Reading

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Mentioned in this Paper

Biological Markers
Metabolic Process, Cellular
Biochemical Pathway
Collection of Blood Specimen for Laboratory Procedure
Magnetic Resonance Imaging
Adverse Effects
Metabolic Syndrome Pathway

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