PMID: 752725Dec 29, 1978Paper

Metabolic stimulation of polymorphonuclear leucocytes: effects of tetravalent and divalent concanavalin A

The Journal of Membrane Biology
D RomeoC Schneider

Abstract

Polymorphonuclear leucocytes (PMNL) undergo a marked activation of their oxidative metabolism upon interaction with surface-reactive soluble stimuli as well as with phagocytosable objects. To get some insight into the mechanism of this stimulation, we have compared the stimulatory activity of the tetravalent lectin concanavalin A (Con A) with that of the divalent derivative succinyl-Con A (S-Con A). Both lectins bind to the PMNL surface to the same extent. S-Con A, however, is much less efficient in stimulating the PMNL metabolism. When S-Con A-treated PMNL are further reacted with antiserum to Con A, a potentiation of the metabolic stimulation is observed. Normal serum or addition to PMNL of antiserum to Con A in the absence of lectin has no effect. Furthermore, if S-Con A is displaced from its receptors on the cell membrane with alpha-methyl mannopyranoside, the addition of antiserum fails to cause a respiratory stimulation. These results suggest that the initial triggering of the metabolic stimulation of PMNL is in part accomplished through cross-linkage of membrane constituents.

References

Jan 1, 1975·Advances in Experimental Medicine and Biology·D RomeoM R Soranzo
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J W HaddenR G Coffey
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D A McClainG M Edelman
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R D Berlin, J P Fera
May 15, 1976·The Biochemical Journal·G Zabucchi, D Romeo
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J L WangG M Edelman
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J SchlessingerE L Elson
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Schekman, S J Singer
Jul 31, 1975·Nature·D MirelmanR Lotan
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
May 26, 1966·Biochimica Et Biophysica Acta·F Rossi, M Zatti
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G R GuntherG M Edelman
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J M OliverR D Berlin
Apr 26, 1974·Biochimica Et Biophysica Acta·K Kakinuma
Nov 28, 1967·Biochimica Et Biophysica Acta·M Zatti, F Rossi
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

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Citations

Nov 1, 1980·Agents and Actions·J G Elferink, R C Riemersma
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G BertonS Gordon
Jul 1, 1983·The Journal of Clinical Investigation·C A DahindenT E Hugli

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