PMID: 1205025Dec 1, 1975Paper

Metabolic studies in familial partial lipodystrophy of the lower trunk and extremities

Diabetologia
M B Davidson, R T Young

Abstract

A familial syndrome of partial lipodystrophy inherited as a dominant trait is reported. Subcutaneous fat loss was confined to the extremities and trunk. Diabetes mellitus, hyperlipidemia, hepatomegaly and renal disease were very prevalent in this family. Metabolic studies were performed on 3 members. In vivo tests suggested that the remaining fat tissue responded normally to stimulators and inhibitors of lipolysis. In vitro incubation of the dystrophic fat tissue of one patient suggested that the intracellular pathways of lipid and glucose metabolism were normal. The pattern of subcutaneous loss of adipose tissue observed in this family may be due to sympathetic nervous system overactivity of certain non-contiguous dermatomes.

References

Jan 1, 1975·Clinical Endocrinology·B J BoucherA S Mason
Dec 1, 1970·Annals of Internal Medicine·R L PiscatelliR J Havel
Sep 22, 1973·Lancet·R A Thompson, R H White
Apr 1, 1966·Metabolism: Clinical and Experimental·L H LouisM C Minick
Aug 1, 1970·European Journal of Clinical Investigation·P Björntorp, M Karlsson
Oct 1, 1970·Annals of Internal Medicine·G A Bray
May 1, 1973·Diabetes·M TzagournisJ Herrold
Jun 1, 1969·Metabolism: Clinical and Experimental·N A Samaan, J W Craig
Jan 1, 1972·European Journal of Clinical Investigation·P Björntorp, L Sjöström
Jul 1, 1972·Diabetes·R KikkawaK Izumi
Jun 1, 1969·The Journal of Pediatrics·B Senior, L Loridan
Aug 1, 1969·The Journal of Clinical Investigation·R P EatonD Steinberg
May 1, 1966·Canadian Journal of Biochemistry·A KahlenbergN Kalant
Apr 1, 1967·The American Journal of Physiology·R B Goldrick
Oct 1, 1967·Diabetes·T Steinberg, G Gwinup
Jul 1, 1961·Archives of Dermatology·W B TAYLOR, W M HONEYCUTT
Feb 1, 1949·The Journal of Nervous and Mental Disease·L BARRAQUER FERRE
Feb 1, 1948·American Journal of Diseases of Children·W W IGERSHEIMER

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Citations

Jan 1, 1983·Human Genetics·R Wettke-Schäfer, G Kantner
Jan 7, 1999·Clinical Endocrinology·J A JanssenS W Lamberts
Jan 1, 1995·International Journal of Dermatology·O GürbüzR Khalilazer
Apr 1, 1986·Journal of Medical Genetics·J Burn, M Baraitser
Nov 1, 1988·Postgraduate Medical Journal·T M DavisG F Joplin
May 1, 1989·Postgraduate Medical Journal·D A Robertson, R Wright
Jun 5, 1998·The Australasian Journal of Dermatology·M M Tam, P Berger
Feb 1, 1997·Metabolism: Clinical and Experimental·M J UrsichB L Wajchenberg
May 1, 1982·Metabolism: Clinical and Experimental·D C RobbinsE A Sims
Nov 1, 1988·Pediatric Dermatology·I K AronsonD Variakojis
May 27, 2003·Diabetes Care·Karen L HerbstAlan Chait
Mar 1, 1986·Annals of the Rheumatic Diseases·N D Broom
Nov 1, 1990·Clinical Genetics·W ReardonM Baraitser
May 1, 1979·Metabolism: Clinical and Experimental·R S BernsteinS B Crespin
Apr 1, 1997·Pediatric Clinics of North America·N S Glaser

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