Metabolic studies in mitral valve prolapse syndrome. A neuroendocrine--cardiovascular process

Circulation
H BoudoulasC F Wooley

Abstract

Symptomatic patients with mitral valve prolapse (MVP) frequently mimic thyrotoxicosis, hyperadrenergic states or hypoglycemia. Twenty symptomatic patients with auscultatory and echocardiographic MVP were studied in the clinical research unit. T3, T4 and plasma cortisol were normal. Patients with MVP had normal responses to oral glucose administration but higher glucose levels than the controls (p less than 0.05). Twenty-four-hour urinary epinephrine (E) and norepinephrine (NE) were greater than normal (E + NE excretion, 44 +/- 2 vs 29.5 microgram/g creatinine, p less than 0.001). The short electromechanical systole corrected for heart rate (529 +/- 3.9 vs normal 548 +/- 2 msec, p less than 0.01) also reflected high adrenergic tone. Frequent premature ventricular complexes (PVCs) with couplets and triplets were found in 14 patients. Catecholamine excretion and frequency of PVCs were parallel and both decreased significantly at night (p less than 0.001). Plasma catecholamine increase with exercise was greater in patients in whom the number of PVCs increased more than 10 per minute compared with patients in whom the number of PVCs remained relatively unchanged (620 +/- 80 vs 98 +/- 20 msec, p less than 0.01). We conclude that symp...Continue Reading

References

Aug 5, 1976·The New England Journal of Medicine·R J Lefkowitz
Oct 26, 1978·The New England Journal of Medicine·S P GalantP A Insel
Oct 1, 1977·Annals of Internal Medicine·H BoudoulasG Dalamangas
Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
Sep 1, 1978·The Annals of Thoracic Surgery·H BoudoulasJ S Vasko
May 1, 1979·Circulation·F A GaffneyC G Blomqvist
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MukherjeeR J Lefkowitz
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Mar 1, 1973·Clinical Science·M M Townshend, A J Smith
Mar 1, 1974·Circulation·R L PoppD C Harrison
Jul 1, 1974·The American Journal of Cardiology·M M LeWinterR A O'Rourke
Mar 1, 1969·Progress in Cardiovascular Diseases·R A Bruce, T R Hornsten
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·I J ChopraR S Ho
Sep 23, 1965·The New England Journal of Medicine·R J Wurtman
Apr 1, 1971·Circulation·J C DillonH Feigenbaum
Feb 1, 1968·Circulation·A M WeisslerC D Schoenfeld
Jul 1, 1969·American Journal of Clinical Pathology·C C Mabry, P W Warth
Jul 1, 1966·British Heart Journal·J M CrileyR S Ross
Dec 21, 1967·The New England Journal of Medicine·F N Pitts, J N McClure
Aug 1, 1953·The Journal of Clinical Endocrinology and Metabolism·N C KLENDSHOJA SPRAGUE

❮ Previous
Next ❯

Citations

Oct 1, 1992·Clinical Cardiology·M Sniezek-MaciejewskaM Kitliński
Dec 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·G MicieliG Nappi
Feb 1, 2011·Pediatric Cardiology·Kadir BabaogluKöksal Binnetoğlu
Jan 5, 2001·Current Treatment Options in Cardiovascular Medicine·H Boudoulas, C F Wooley
Jun 1, 1982·Journal of Affective Disorders·R R CroweR Kerber
Jan 1, 1985·Psychiatry Research·R M NesseM J Huber-Smith
Jan 1, 1987·Psychiatry Research·S R DagerD L Dunner
Jan 1, 1988·Psychoneuroendocrinology·O G Cameron, R M Nesse
Mar 1, 1988·Journal of the American College of Cardiology·T M BashoreC F Wooley
Dec 1, 1989·Journal of the American College of Cardiology·E D Frohlich
Oct 1, 1983·Journal of the American College of Cardiology·H BoudoulasC F Wooley
Jan 1, 1986·Journal of the American College of Cardiology·R M Jeresaty
Mar 4, 1999·Histopathology·M J Davies
Aug 27, 1981·The New England Journal of Medicine·B J ChannickJ F Spann
Apr 7, 1983·The New England Journal of Medicine·D J DobmeyerS F Schaal
Feb 24, 2000·The New England Journal of Medicine·J R ShannonD Robertson
Oct 6, 2000·The New England Journal of Medicine·G JacobD Robertson
May 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·C D CasatK E Smith
Aug 1, 1991·Acta Paediatrica Japonica; Overseas Edition·N OharaH Kato
Jul 1, 1992·Pacing and Clinical Electrophysiology : PACE·S Lévy
Mar 28, 1998·Acta Psychiatrica Scandinavica·T HamadaF Gejyo
Jan 1, 1994·Journal of the American Academy of Nurse Practitioners·K S Styres
Dec 23, 2006·BMJ : British Medical Journal·Stefan N Willich
Aug 1, 1982·British Heart Journal·E G Abinader, J Shahar
Apr 1, 1985·British Heart Journal·A BraumanD Stryjer
Mar 12, 1999·Annual Review of Medicine·G T Altemose, A E Buxton
Nov 30, 2010·Cardiology Research and Practice·Andreas P MichaelidesChristodoulos I Stefanadis
Mar 15, 1997·The American Journal of Cardiology·B LichodziejewskaL Ceremuzyński
Jun 1, 1993·Journal of Cardiovascular Electrophysiology·P Coumel
Jul 1, 1996·Anesthesiology·E W HansonC Lynch
Jun 23, 2001·The American Journal of the Medical Sciences·W JacobsG A Stouffer
Aug 1, 1991·The American Journal of the Medical Sciences·A AnwarM S Katz
Nov 1, 1989·Chest·Y DroryJ J Kellermann
Nov 1, 1985·Psychosomatics·R H Rosenman
Aug 8, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hatice Duygu BasFrank Bogun
Jul 1, 1986·Disease-a-month : DM·R R Crowe, R Noyes
Jun 16, 2010·Pacing and Clinical Electrophysiology : PACE·Murat AkcayMehmet Ozkan
Mar 1, 1992·American Heart Journal·K HirataC F Wooley
May 29, 2007·The American Journal of Cardiology·Gülten TaçoyAtiye Cengel
Dec 1, 1982·The American Journal of Medicine·A PasternacJ de Champlain
May 1, 1987·The American Journal of Medicine·N J WeissmanR B Devereux
May 1, 1994·The American Journal of Cardiology·E G AbinaderE Goldhammer
Sep 1, 1984·Progress in Cardiovascular Diseases·M H Crawford, R A O'Rourke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.