PMID: 1201271Nov 1, 1975Paper

Metabolic studies of [75Se]selenocystine and [75Se]selenomethionine in the rat

The British Journal of Nutrition
C D ThomsonM F Robinson

Abstract

1. The long-term fate in rats of an oral dose of [75Se]selenocystine was compared with that of an oral dose of [75Se]selenomethionine. 2. Urinary and faecal radioactivities were measured during the 1st week and whole-body radioactivity was determined for 10 weeks. Rats were killed at weekly intervals for 4 weeks and at weeks 6 and 10 for analysis of tissue distribution of 75Se. 3. Intestinal absorption of [75Se]selenocystine was 81% of the administered dose; that of [75Se]selenomethionine was 86%. Urinary excretion of absorbed [75Se]selenocystine was 13-9% and that of [75Se]selenomethionine was 5-8% in the 1st week. 4. Whole-body retention of 75Se was greater for [75Se]selenomethionine than for [75Se]selenocystine but after the 1st week it decreased at a similar rate in both groups. Tissue distribution of retained 75Se was also similar in both groups. 5. The initial utilization of [75Se]selenocystine was different from that of [75Se]selenomethionine. However, after the 1st week 75Se from both sources appeared to be metabolized similarly, suggesting that dietary Se of both forms is ultimately incorporated into the same metabolic pool. 6. When these findings were compared with those of earlier studies with [75Se]selenite and 75Se...Continue Reading

References

Jan 1, 1975·The British Journal of Nutrition·C D ThomsonM F Robinson
Jul 1, 1973·The British Journal of Nutrition·C D Thomson, R D Stewart
Oct 1, 1972·CRC Critical Reviews in Toxicology·D V Frost
Mar 8, 1974·Science·T C Stadtman
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·R F BurkK W Kiker
Feb 1, 1973·Journal of Animal Science·E E CaryM Miller
Jun 1, 1969·The American Journal of Clinical Nutrition·L Lutwak

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Citations

Feb 4, 2011·The Journal of Nutrition·Meryl E WastneyBlossom H Patterson
Apr 22, 2015·Critical Reviews in Food Science and Nutrition·Jorge Moreda-PiñeiroPilar Bermejo-Barrera
Jul 1, 1977·The British Journal of Nutrition·M RicholdR D Stewart
Jul 1, 1978·The British Journal of Nutrition·R D StewartM F Robinson
May 1, 1976·The British Journal of Nutrition·N M GriffithsM F Robinson
Apr 1, 1976·Journal of Human Nutrition·M F Robinson
Jan 1, 1982·Drug Metabolism Reviews·B A BoppJ W Kesterson
Jan 30, 2004·European Journal of Clinical Nutrition·T E FoxS J Fairweather-Tait
May 1, 1983·Molecular and Cellular Endocrinology·P J Hornsby, J F Crivello
Dec 19, 2012·Journal of Proteome Research·Yu-Dong WangYum-shing Wong

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