Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus.

Nature Reviews. Endocrinology
Francesco RubinoTimothy E McGraw

Abstract

Several conventional methods of bariatric surgery can induce long-term remission of type 2 diabetes mellitus (T2DM); novel gastrointestinal surgical procedures are reported to have similar effects. These procedures also dramatically improve other metabolic conditions, including hyperlipidemia and hypertension, in both obese and nonobese patients. Several studies have provided evidence that these metabolic effects are not simply the results of drastic weight loss and decreased caloric intake but might be attributable, in part, to endocrine changes resulting from surgical manipulation of the gastrointestinal tract. In this Review, we provide an overview of the clinical evidence that demonstrates the effects of such interventions-termed metabolic surgery-on T2DM and discuss the implications for future research. In light of the evidence presented here, we speculate that the gastrointestinal tract might have a role in the pathophysiology of T2DM and obesity.

References

May 1, 1997·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K G MacDonaldW J Pories
Aug 29, 2001·Annals of Surgery·S F KhuriUNKNOWN VA National Surgical Quality Improvement Program
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Oct 8, 2003·Annals of Surgery·Philip R SchauerDavid Kelley
Aug 21, 2004·Annals of Surgery·Nicolas V ChristouLloyd D MacLean
Sep 30, 2004·Journal of the American College of Surgeons·David R Flum, E Patchen Dellinger
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Judith KornerSharon L Wardlaw
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Jun 11, 2005·Obesity Surgery·Kusal WickremesekeraRichard S Stubbs
Jun 8, 2006·Obesity Surgery·Nicola Scopinaro
Aug 24, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ricardo CohenCarlos A Schiavon
Oct 4, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ricardo Cohen
Jan 2, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Oluseun A SowemimoRandolph B Reinhold
Mar 28, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·David E CummingsMolly J Carlson
Mar 28, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ricardo V CohenFrancesco Rubino
Apr 12, 2007·Advances in Food and Nutrition Research·Magdalena Pasarica, Nikhil V Dhurandhar
Jul 31, 2007·Journal of the American College of Surgeons·Ninh T NguyenSamuel E Wilson
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Aug 24, 2007·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Oct 13, 2007·ANZ Journal of Surgery·Susan S H GanJohn O Jorgensen
Oct 18, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wei-Jei LeeJung-Chien Chen
Oct 31, 2007·Annals of Surgery·Carel W le RouxTorsten Olbers
Nov 29, 2007·Annals of Surgery·Anna PeetersJohn Dixon
Dec 25, 2007·Annals of Surgery·Cynthia D PerryBarbara J McNeil
Jan 19, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Leonardo Rodriguez-GrunertMichael Tarnoff
Jan 24, 2008·JAMA : the Journal of the American Medical Association·John B DixonMargaret Anderson
Mar 5, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Tracy-Ann Moo, Francesco Rubino

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Citations

Aug 27, 2011·Langenbeck's Archives of Surgery·M GassR Peterli
Feb 22, 2012·Surgical Endoscopy·Monika Proczko-MarkuszewskaZbigniew Sledziński
Apr 5, 2013·Frontiers of Medicine·Bing LiHuarong Zhou
Oct 18, 2011·Obesity Surgery·Jonathan FooRichard Strawson Stubbs
Oct 18, 2012·Current Atherosclerosis Reports·Ashwin SoniFrancesco Rubino
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aaron D TalsmaIrene Miguel-Aliaga
May 2, 2012·Metabolic Syndrome and Related Disorders·Carlos SaboyaGaspar Jesus Lopes-Filho
Sep 7, 2012·Diabetes, Obesity & Metabolism·P E Harris, R L Leibel
Jul 20, 2012·Physiological Reviews·Nada A Abumrad, Nicholas O Davidson
May 3, 2012·Endocrine Reviews·Margaret A StefaterRandy J Seeley
Aug 24, 2012·Molecular Endocrinology·Norman SimpsonPaul E Harris
Dec 15, 2011·Polski przeglad chirurgiczny·Monika Proczko-MarkuszewskaZbigniew Sledziński
Jan 10, 2012·World Journal of Gastroenterology : WJG·Jong Won KimSung Hoon Noh
Nov 20, 2013·Annual Review of Physiology·Young Min ChoTimothy J Kieffer
Mar 14, 2012·Obesity Surgery·Allan Cezar Faria AraujoAlexandre Coutinho Teixeira de Freitas
Mar 15, 2011·World Journal of Surgery·Vivek N Prachand
Feb 24, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mee Joo KangSun-Whe Kim
Feb 2, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alper CelikMuhammad Abdul-Ghani
Aug 6, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Ana M Ramos-Leví, Miguel A Rubio Herrera
Feb 5, 2013·Seminars in Nephrology·Hermann J Kissler, Utz Settmacher
Jan 3, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·J B DixonP Zimmet
Nov 28, 2012·Surgery·Taufiek Konrad Rajab, James Watkins
Jun 5, 2012·Pharmacology & Therapeutics·Young Min ChoTimothy J Kieffer
Jan 14, 2016·Obesity Surgery·Baiyu YangKatherine A McGlynn
Apr 17, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Albert LecubeUNKNOWN en nombre del Grupo de Trabajo de Obesidad de la Sociedad Española de Endocrinología y Nutrición (GOSEEN)
Nov 19, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Juan José Gorgojo Martínez
Dec 6, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Yu-Hsi KaoChih-Kun Huang
Jul 1, 2011·Obesity Research & Clinical Practice
Jul 26, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·J B DixonUNKNOWN International Diabetes Federation Taskforce on Epidemiology and Prevention
Nov 30, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Silvana Pannain, Babak Mokhlesi
Jun 15, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jun-Min ChoRaul J Rosenthal
Apr 13, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J B DixonUNKNOWN International Diabetes Federation Taskforce on Epidemiology and Prevention
Apr 22, 2011·Cancer·Hutan AshrafianThanos Athanasiou
Jul 27, 2012·Pediatric Diabetes·M A StefaterT H Inge
Oct 21, 2010·The Mount Sinai Journal of Medicine, New York·Kervin ArroyoDaniel M Herron

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