Metabolic switches linked to pluripotency and embryonic stem cell differentiation

Cell Metabolism
Ng Shyh-Chang, George Q Daley

Abstract

Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.

References

May 23, 2009·Science·Kathryn E WellenCraig B Thompson
Mar 17, 2010·Current Opinion in Cell Biology·Anna Mattout, Eran Meshorer
May 30, 2013·Development·Ng Shyh-ChangLewis C Cantley
Sep 12, 2014·Nature·Warren Mansell, Timothy A Carey

❮ Previous
Next ❯

Citations

Jan 27, 2016·Trends in Endocrinology and Metabolism : TEM·Elwin Tan Jun-HaoNg Shyh-Chang
Feb 7, 2016·Seminars in Cell & Developmental Biology·Jason Chua Min-WenNg Shyh-Chang
Nov 20, 2016·The FEBS Journal·Thomas Riffelmacher, Anna-Katharina Simon
Mar 21, 2017·Genes & Development·Ng Shyh-Chang, Huck-Hui Ng
Apr 28, 2017·Nature Cell Biology·Tong Ming Liu, Ng Shyh-Chang
Jun 27, 2017·Cell Metabolism·Hsiuchen Chen, David C Chan
Feb 16, 2017·Development·Julie Mathieu, Hannele Ruohola-Baker
Oct 17, 2018·Journal of Mass Spectrometry : JMS·Camila Bruna de LimaR Graham Cooks
Jun 4, 2016·Molecular Medicine·Zhiqiang ZhaoLijun Di
May 10, 2019·International Journal of Molecular Sciences·Ken NishimuraKoji Hisatake
Mar 15, 2019·Current Stem Cell Research & Therapy·Maryam FarzanehSeyed Esmaeil Khoshnam
Jan 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Peng LiLingyi Chen
Oct 1, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leah C WehmasCharles E Wood
Oct 1, 2019·Cell Cycle·Maria Teresa Fiorenza, Alessandro Rava
Oct 25, 2017·Analytical Methods : Advancing Methods and Applications·Rosemary M OnjikoPeter Nemes
Mar 7, 2021·International Journal of Molecular Sciences·Anna Laura VoigtIna Dobrinski
Dec 7, 2021·Frontiers in Veterinary Science·Cristina CuelloEmilio A Martinez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.