PMID: 25738450DOI: 10.1016/j.cmet.2015.02.011Mar 5, 2015Paper
Metabolic switches linked to pluripotency and embryonic stem cell differentiation
Cell Metabolism
Ng Shyh-Chang, George Q Daley
Abstract
Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.
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Jan 27, 2016·Trends in Endocrinology and Metabolism : TEM·Elwin Tan Jun-HaoNg Shyh-Chang
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