Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism

Annals of the New York Academy of Sciences
Gregory F Oxenkrug

Abstract

The neuroendocrine theory of aging identified a cluster of conditions (hypertension, obesity, dyslipidemia, diabetes type 2, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer, e.g., breast and prostate) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndromes (MetS). Chronic inflammation is currently considered as a common feature of MetS/AAND. One of the mechanisms by which chronic inflammation might trigger and/or maintain the development of MetS/AAND is transcriptional induction of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of tryptophan (TRY)-kynurenine (KYN) pathway, by pro-inflammatory cytokines (PIC). Activation of IDO shifts TRY metabolism from serotonin synthesis to formation of "kynurenines." Diminished serotonin production is associated with mental depression while increased formation of kynurenines might contribute to development of MetS/AAND via their apoptotic, neurotoxic, and pro-oxidative effects, and upregulation of inducible nitric oxide synthase, phospholipase A2, arachidonic acid, prostaglandin, 5-lipoxygenase, and leukotriene cascad...Continue Reading

References

Mar 1, 1989·Journal of Neurochemistry·J H ConnickT W Stone
Mar 1, 1980·Neurochemical Research·E M Gál, A D Sherman
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·J A FinkelsteinJ E Fischer
Jan 1, 1984·Journal of Pineal Research·G F OxenkrugS Gershon
Feb 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·H WolfR A Arend
Jan 1, 1996·Advances in Experimental Medicine and Biology·I P Lapin
Oct 13, 1998·Life Sciences·I P Lapin
Apr 3, 2001·The International Journal of Neuropsychopharmacology·Irine V. Prakhie, Gregory F. Oxenkrug
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·J DahlgrenA Holmäng
Jul 13, 2001·Menopause : the Journal of the North American Menopause Society·K DeguchiT Aono
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken-ichi MizutaniNaoharu Iwai
Jul 30, 2002·The Journal of Biological Chemistry·John B J KwokVimal Kapoor
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert Schwarcz, Roberto Pellicciari
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Gunter Kenis, Michael Maes
Feb 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M F EliasR B D'Agostino
Mar 4, 2003·CNS Spectrums·Gregory F Oxenkrug, Pura J Requintina
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Molly C Carr
Jun 20, 2003·European Journal of Clinical Investigation·B WirleitnerD Fuchs
Jun 20, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anthony RongvauxOberdan Leo
Jan 15, 2005·Sleep Medicine Reviews·Amnon BrzezinskiIan Ford
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cory M RobinsonJoseph M Carlin
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Olga J G SchiepersMichael Maes
Sep 24, 2005·Annals of the New York Academy of Sciences·Mary C PerianayagamBertrand L Jaber

❮ Previous
Next ❯

Citations

Dec 17, 2010·Journal of Neural Transmission·G OxenkrugP Summergrad
Sep 13, 2011·Journal of Proteome Research·Sara TulipaniCristina Andrés-Lacueva
May 24, 2012·Obstetrics and Gynecology·Roy M NilsenPer Magne Ueland
Nov 16, 2013·BMC Medicine·Almudena Sánchez-VillegasLluis Serra-Majem
Oct 15, 2011·Cellular and Molecular Life Sciences : CMLS·Akhlaq A FarooquiVincenza Frisardi
Sep 4, 2012·Journal of the Neurological Sciences·Lin TanLan Tan
May 4, 2011·The Psychiatric Clinics of North America·Francis E Lotrich
Jun 1, 2011·Ageing Research Reviews·Perla KalimanMercè Pallàs
Jul 15, 2015·Reviews in the Neurosciences·Alexander V Kulikov, Nina K Popova
Oct 1, 2014·Nutritional Neuroscience·Hanna Karakuła-JuchnowiczZofia Lasik
Sep 15, 2015·Metabolomics : Official Journal of the Metabolomic Society·Norihide YokoiSusumu Seino
Apr 3, 2014·Oxidative Medicine and Cellular Longevity·Mohammad Amin RezvanfarMohammad Abdollahi
Dec 30, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cynthia L BetheaJon E Levine
Jun 2, 2012·Nutrition Research·Katri PeuhkuriRiitta Korpela
May 15, 2013·Journal of Affective Disorders·Hui Hua ChangPo See Chen
Sep 15, 2016·Psychoneuroendocrinology·Pascal BaratLucile Capuron
Oct 13, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sally A AbuelezzYosra Magdy
Mar 8, 2016·Diabetes/metabolism Research and Reviews·Jonathan M MudryHarriet Wallberg-Henriksson
May 20, 2011·Cephalalgia : an International Journal of Headache·Song GuoMessoud Ashina
Dec 28, 2017·The Journal of Biological Chemistry·Seung-Hyeon SeokYongna Xing
Jan 1, 2013·International Journal of Tryptophan Research : IJTR·Odile Poulain-GodefroyPhilippe Froguel
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Wesam M El-Bakly, Amany H Hasanin
May 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo ZhangHong-Sheng Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.