Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission

Acta Psychiatrica Scandinavica
H BrochardB Etain

Abstract

This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD). Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status. We found correlations between lower sleep efficiency and higher triglyceride levels (P = 0.002), lower M10 onset (beginning of the 10 most active hours during the 24-h cycle) and higher systolic blood pressure (P = 0.03), higher fragmentation index and higher systolic blood pressure (P = 0.009), lower sleep efficiency, higher fragmentation index, and higher AIP (respectively P = 0.02 and P = 0.04). These correlations mostly remained significant when adjusting for confounders, with the exception of M10 onset and systolic blood pressure. Sleep efficiency and fragmentation index might contribute to the cardiovascular risk of patient...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Oct 3, 1999·Annals of Internal Medicine·N C NetzerK P Strohl
May 16, 2009·Chronobiology International·Isabella SorecaDavid J Kupfer
Sep 4, 2012·Bipolar Disorders·Isabella SorecaDavid J Kupfer
Dec 5, 2012·Behavioral Sleep Medicine·Carole BoudebesseAnne Germain
Mar 25, 2014·Journal of Affective Disorders·Pierre Alexis GeoffroyBruno Etain
Jun 4, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F WangL A Tse
Jun 9, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·C BoudebesseB Etain
Jul 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amanda J RossJason R Carter
Nov 6, 2014·The Journal of Clinical Psychiatry·Ophélia GodinUNKNOWN FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Nov 29, 2014·Acta Psychiatrica Scandinavica·P A GeoffroyB Etain
Mar 5, 2015·Acta Psychiatrica Scandinavica·J F HayesD P J Osborn
Apr 24, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yan WangFan Jiang
Jun 20, 2015·Current Pharmaceutical Design·Pierre Alexis GeoffroyPhilipp Ritter
Jul 15, 2015·Annals of the American Thoracic Society·Imran H IftikharUlysses J Magalang
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Davy VancampfortChristoph U Correll
Aug 16, 2016·Sleep Medicine Reviews·Matias C A MeloVeralice M S de Bruin
Sep 25, 2016·L'Encéphale·H BrochardB Étain
Feb 12, 2017·Sleep Medicine Reviews·Franco De CrescenzoDigby J Quested
Mar 16, 2017·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
May 26, 2017·Chronobiology International·Pierre A GeoffroyUNKNOWN FACE-BD coll
Sep 12, 2017·Sleep Medicine Reviews·Maki JikeYoshitaka Kaneita

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Citations

Nov 21, 2020·International Journal of Bipolar Disorders·Henrik Myhre IhlerBruno Etain

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