Metabolic syndrome and cerebrovascular impairment in Alzheimer's disease

International Journal of Geriatric Psychiatry
Giovanna ViticchiMauro Silvestrini

Abstract

Metabolic Syndrome (MeS) has inconstantly been associated with cognitive impairment. The aim of this study was to investigate the influence of MeS on cerebrovascular reactivity and the possible consequences on cognitive impairment in patients with Alzheimer's disease (AD). A total of 162 AD patients were enrolled and grouped depending on the presence/absence of MeS. An ultrasound assessment of the neck vessels was performed to evaluate common carotid artery intima-media thickness (IMT). Cerebral hemodynamics was assessed by the transcranial Doppler-based breath-holding index (BHI) test. The relationship between BHI and MeS was explored first with a nested binary logistic model and then with a general linear model/adjusted model. Both models were corrected for sex, age, education, BMI, smoking attitude, and IMT treated as covariates. Pathologic BHI values were significantly more frequent among patients with MeS (risk ratio (RR):1.477; 95% CI: 1.177-1.848). MeS significantly improved the prediction of a pathologic BHI in the binary logistic model (odds ratio (OR):11.64; 95% CI: 1.001-135.304; p < 0.05). Moreover, AD patients affected by MeS had significantly lower mean Mini-Mental State Evaluation values than the unaffected ones ...Continue Reading

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Citations

Aug 5, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Siobhan M HoscheidtBarbara B Bendlin
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Giovanna ViticchiMauro Silvestrini
Jul 4, 2017·Journal of Alzheimer's Disease : JAD·Lucy BeishonThompson G Robinson
Aug 29, 2020·International Journal of Geriatric Psychiatry·Giovanna ViticchiMauro Silvestrini
Oct 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cillian E LynchCorbin Bachmeier

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