Metabolic syndrome and coronary artery disease: is there a gender specific effect?

International Journal of Cardiology
José R LanzJosé E Krieger

Abstract

Clustering of cardiovascular risk factors is observed in metabolic syndrome (MS), but the relative contribution of different factors to determine outcomes remains largely unknown. We investigated the influence of gender in the effect of MS in coronary vascular lesions in 385 patients who underwent first time coronary artery disease (CAD) assessment through coronary angiography. Patients were stratified in two groups: metabolic syndrome (MS, N = 190) and non-metabolic syndrome (NMS, N = 195), according to standard criteria. Two vascular scores related to extension and severity of vascular lesions were determined by systematic analysis of 20 coronary segments. MS was more prevalent in females (58.7 vs. 39.7%, p = 0.0005) and hypertension and low-HDL were the leading prevalent factors in the MS group. Scores for extension and severity of lesions were higher in the MS than in the NMS group (2.10 +/- 1.75 vs. 1.75 +/- 1.58; p = 0.01, and 1.49 +/- 1.29 vs. 1.25 +/- 1.15; p = 0.03, respectively). The impact of MS in CAD scores was more pronounced in females (OR 2.2, 95% CI 1.1-4.3, p = 0.02) than in males (OR 1.5, 95% CI 0.8-2.7, p = 0.17). Non-HDL cholesterol was the only risk factor influencing the scores in a gender specific manner...Continue Reading

References

Jun 1, 1988·The American Journal of Cardiology·A MoiseJ Saltiel
Jul 1, 1996·Atherosclerosis·W P Castelli
Feb 19, 2002·Atherosclerosis·Agnès PascotJean Pierre Després
Nov 13, 2002·Circulation·Vera BittnerUNKNOWN Bypass Angioplasty Revascularization Investigation
Apr 30, 2003·Diabetes·Charles M AlexanderUNKNOWN National Cholesterol Education Program (NCEP)

❮ Previous
Next ❯

Citations

Feb 17, 2010·Metabolic Syndrome and Related Disorders·Dimitris M KonstantinouGeorge D Giannoglou
Jun 30, 2012·Lipids in Health and Disease·Paulo C J L SantosAlexandre C Pereira
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Israel Pérez-TorresGuadalupe Baños
Oct 3, 2006·International Journal of Cardiology·Mehmet Birhan Yilmaz
Oct 27, 2005·International Journal of Cardiology·Hasan TurhanErsoy Isik
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.