Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs

Molecular Metabolism
Simone RennerEckhard Wolf

Abstract

The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central to experimental studies of disease mechanisms and therapeutic strategies. Diet-induced obesity (DIO) models in rodents have provided important insights into the pathophysiology of obesity and, in most instances, are the first in line for exploratory pharmacology studies. To deepen the relevance towards translation to human patients, we established a corresponding DIO model in Göttingen minipigs (GM). Young adult female ovariectomized GM were fed a high-fat/high-energy diet for a period of 70 weeks. The ration was calculated to meet the requirements and maintain body weight (BW) of lean adult minipigs (L-GM group) or increased stepwise to achieve an obese state (DIO-GM group). Body composition, blood parameters and intravenous glucose tolerance were determined at regular intervals. A pilot chronic treatment trial with a GLP1 receptor agonist was conducted in DIO-GM. At the end of the study, the animals were necropsied and a biobank of selected tissues was established. DIO-GM developed severe subcutaneous and visceral...Continue Reading

Citations

Dec 7, 2018·Nature Reviews. Endocrinology·Mostafa BakhtiHeiko Lickert
Oct 28, 2019·Toxicologic Pathology·Birgitte Martine ViuffBerit Ø Christoffersen
Jan 15, 2020·Cell and Tissue Research·Simone RennerEckhard Wolf
Mar 3, 2020·Annual Review of Biomedical Engineering·Michael SturekFrank W Sellke
Jan 9, 2019·Frontiers in Microbiology·Hua YangYingping Xiao
Mar 5, 2020·Cell and Tissue Research·Amanda P Beck, David K Meyerholz
Nov 27, 2019·Molecular Metabolism·T D MüllerM H Tschöp
Apr 27, 2021·American Journal of Physiology. Renal Physiology·Jianni HuangShougang Zhuang
Sep 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth KemterMichele Solimena

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Methods Mentioned

BETA
X-ray
electron microscopy

Software Mentioned

GraphPad Prism
SAS
ARRIVE

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