Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats

BioMed Research International
Julie DupasJacques Mansourati

Abstract

Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C;n= 14) and fructose fed (FF;n= 18), with a fructose enriched drink (20-25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were measured concomitantly and insulin resistance markers were evaluated (HOMA 2-IR, Insulin Sensitivity Index for glycemia (ISI-gly)). Lipids profile was evaluated on plasma. This fructose supplementation resulted in the early induction of hypertension without renal failure (stable theoretical creatinine clearance) and in the progressive development of fasting hyperglycemia and insulin resistance (higher HOMA 2-IR, lower ISI-gly) without modification of glucose tolerance. FF rats presented dyslipidemia (higher plasma triglycerides) and early sign of liver malfunction (higher liver weight). Although abdominal fat weight was increased i...Continue Reading

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Citations

Jun 27, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mina KimInkyeom Kim
Feb 19, 2020·Clinical and Experimental Dental Research·Shalinie KingTara C Brennan-Speranza
Oct 12, 2018·Nutrition & Metabolism·Julie DupasChristelle Goanvec
Dec 29, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mina Kim, Inkyeom Kim
Feb 27, 2021·Archives of Physiology and Biochemistry·Mervat H El-SakaNermin M Madi
May 29, 2020·Interdisciplinary Toxicology·Michaela SasváriováTatiana Stankovičová

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Methods Mentioned

BETA
ELISA
electrophoresis
PCR

Software Mentioned

ISI
gly
HOMA 2 - IR calculator

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