Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: a prospective cohort study

Atherosclerosis
Tao ZhangFuzhong Xue

Abstract

To explore the longitudinal effect of metabolic syndrome (MetS) and its components on the development of non-alcoholic fatty liver disease (NAFLD) and to evaluate the significance of MetS and its components as early markers of NAFLD risk in a northern urban Han Chinese population. A total of 15,791 cohort members without NAFLD at baseline were included in the current study between 2005 and 2011. The baseline characteristics of the cohort were compared by MetS status at baseline and NAFLD status after follow-up. Cox proportional hazards models were used to estimate the unadjusted or adjusted hazard ratios (HRs) for development of NAFLD among individuals with MetS compared with individuals without MetS at baseline. During 51,652 person-years of follow-up, 3913 (24.78%) new cases of NAFLD occurred between 2005 and 2011. In the unadjusted model, the HR (95% confidence interval [CI]) for NAFLD was 2.51 (2.30, 2.73). After adjusting for gender, age, diet, smoking status, and regular exercise, the HR was 1.94 (1.78, 2.13). Gender differences were observed, with adjusted HRs (95% CIs) of 1.89 (1.71, 2.09) and 1.72 (1.43, 2.07) among males and females, respectively. Compared with individuals without MetS components, the HRs were 1.92 (1...Continue Reading

References

Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·F AngelicoF Violi
Jul 12, 2005·Journal of Hepatology·Jian-Gao FanShi-Yao Chen
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Nov 17, 2005·Annals of Internal Medicine·Masahide HamaguchiKazunori Ida
May 20, 2006·Current Medical Research and Opinion·Vasilios G AthyrosMoses S Elisaf
Apr 28, 2007·World Journal of Gastroenterology : WJG·Masahide HamaguchiToshikazu Yoshikawa
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Shivakumar ChitturiUNKNOWN Asia-Pacific Working Party on NAFLD
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Apr 19, 2008·Journal of Digestive Diseases·Min De ZengUNKNOWN Chinese National Consensus Workshop on Nonalcoholic Fatty Liver Disease
Aug 19, 2008·Southern Medical Journal·Chung-Huang TsaiCheng-Chieh Lin
Oct 22, 2008·Trends in Endocrinology and Metabolism : TEM·Herbert Tilg, Alexander R Moschen
Nov 19, 2008·Journal of Hepatology·Jian-Gao Fan, Geoffrey C Farrell
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa FabbriniSamuel Klein
Apr 18, 2012·World Journal of Gastroenterology : WJG·Masahide HamaguchiJun Takeda
Aug 14, 2012·Lancet·Ele Ferrannini, William C Cushman
Jun 27, 2013·World Journal of Gastroenterology : WJG·Giovanni Tarantino, Carmine Finelli
Nov 14, 2013·Journal of Gastroenterology and Hepatology·ZhanZhan LiLiYa Liu

❮ Previous
Next ❯

Citations

Mar 16, 2016·International Journal of Molecular Sciences·Patrick Wainwright, Christopher D Byrne
Mar 30, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L LiB Wang
Aug 11, 2016·Metabolism: Clinical and Experimental·Tingting DuXuefeng Yu
Mar 5, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yaohui WangZhiheng Chen
Oct 13, 2016·Journal of Hepatology·Jiantao MaMichelle T Long
Jan 24, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Jie ZhouMing-Hua Zheng
Jan 30, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Michelle T LongEmelia J Benjamin
May 31, 2018·Medicinal Research Reviews·Jingjing CaiHongliang Li
Jun 20, 2018·European Journal of Gastroenterology & Hepatology·Dimitrios OikonomouDimitrios Tousoulis
May 8, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuanjie PangZhengming Chen
Apr 6, 2019·The American Journal of Gastroenterology·Dana de Gracia HahnJake P Mann
Sep 6, 2019·Animals : an Open Access Journal From MDPI·Yadong WangMing Li
Feb 4, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Huamin LiuYong Zhou
Dec 24, 2019·Hypertension·Yan-Ci ZhaoHongliang Li
Dec 26, 2019·Digestive Diseases and Sciences·Lukas W UngerThomas Reiberger
Jul 27, 2018·European Journal of Gastroenterology & Hepatology·Dimitrios OikonomouDimitrios Tousoulis
May 9, 2019·International Journal of Molecular Sciences·Hamza El HadiMarco Rossato
Aug 11, 2021·BMC Gastroenterology·Yuta YoshimuraMichiaki Fukui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.