Metabolic syndrome and mild to moderate chronic kidney disease among minorities

Seminars in Nephrology
Sankar D NavaneethanTitte R Srinivas

Abstract

The incidence and prevalence of metabolic syndrome and chronic kidney disease (CKD) are increasing in the US population as a whole, but much more rapidly among ethnic minorities. Recent studies have shown that metabolic syndrome is an independent risk factor for the development of incident CKD in African Americans and American Indians distinct from its impact on cardiovascular and all-cause mortality. The pathogenesis of metabolic syndrome in ethnic minorities often is multifactorial. We review the myriad facets of the impact of the metabolic syndrome on the pathophysiology of CKD in minorities. In addition to classic biochemical and physiologic factors, increasing attention is being drawn to the major role of novel factors such as adiponectin and socioeconomic and cultural factors in the development of obesity and insulin resistance; an understudied area that may modulate clinically relevant consequences of biochemical and pathophysiologic aberrations. We present an integrated pathophysiologic viewpoint that incorporates insights from basic science, socioeconomic inquiry, and clinical studies into a framework for clinical practice and investigation.

References

Jul 1, 1993·Journal of Internal Medicine·I ZavaroniG M Reaven
Jun 9, 2001·The American Journal of Cardiology·K R TuttleR J Johnson
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Dec 19, 2002·Health Care for Women International·Gwen M FeltonAbbas S Tavakoli
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Ele FerranniniRalph A DeFronzo
Jul 17, 2003·Kidney International. Supplement·Bonita Falkner
Sep 6, 2003·The American Journal of Cardiology·Willa A Hsueh, Manuel J Quiñones
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Chi-Yuan HsuMichael G Shlipak
Nov 8, 2003·Hypertension·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Mar 17, 2005·Circulation·Sidney C SmithUNKNOWN American Heart Association Obesity, Metabolic Syndrome, and Hypertension Writing Group
May 20, 2005·Journal of the American Society of Nephrology : JASN·Manjula KurellaGlenn M Chertow
Jun 23, 2005·Social Science & Medicine·Ana F Abraído-LanzaKaren R Flórez
Sep 28, 2005·Diabetes Care·Caroline S FoxDaniel Levy
Jan 6, 2006·Medicine and Science in Sports and Exercise·Martha L SlatteryTim Byers
Nov 4, 2006·Journal of the American Society of Nephrology : JASN·Carmen A PeraltaMichael Shlipak
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Maruja Navarro-DíazJordi Bonal
Feb 3, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing ChenJiang He
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·A Enrique Caballero
Dec 25, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jaime LucoveMarie Russell
Feb 8, 2008·Nutrition Reviews·Jennifer L Black, James Macinko
Apr 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Janice LeaUNKNOWN AASK Study Investigators
Nov 21, 2008·The New England Journal of Medicine·James B MeigsL Adrienne Cupples
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanSrinivasan Beddhu
Aug 1, 2009·Journal of Evidence-based Medicine

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Citations

Nov 12, 2013·Archives of Medical Research·Rita A Gómez-DíazNiels H Wacher
Apr 12, 2011·Revista española de cardiología·Lilach O Lerman, Amir Lerman
Jul 25, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Luis Martínez-DolzJose Anastasio Montero
May 28, 2011·Journal of the American Society of Nephrology : JASN·Mary E Choi

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