Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study

Cancer Causes & Control : CCC
Rhonda S ArthurThomas E Rohan

Abstract

Obesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity. We examined the association of MetS and its components with risk of endometrial cancer in a sub-cohort of 24,210 women enrolled in the Women's Health Initiative cohort study. Two variants of the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS were used: one including and one excluding waist circumference (WC). Cox proportional hazards models were used to estimate the association of the study exposures with disease risk. When WC was included in the definition, MetS showed an approximately two-fold increase in endometrial cancer risk (HR 2.20; 95% CI 1.61-3.02); however, when WC was excluded, MetS was no longer associated with risk. We also observed that women with hyperglycemia, dyslipidemia and hypertension, in combination, had almost a twofold increased risk of endometrial cancer, independent of WC (HR 1.94; 95% CI 1.09, 3.46). Glucose, and, in particular, WC and body mass index were also positively associated with risk. Our findings suggest that MetS may predict risk of endometrial cancer independen...Continue Reading

References

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Citations

Aug 24, 2019·Frontiers in Oncology·Xiao Yang, Jianliu Wang
Jun 5, 2020·American Journal of Obstetrics and Gynecology·Nathan G KaseDerek LeRoith
Jul 23, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Marco MarianiStefania Boccia

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