PMID: 16524527Mar 10, 2006Paper

Metabolic syndrome and the risk of placental dysfunction

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Joel G RayDonald A Redelmeier

Abstract

Placental dysfunction (PD), which may manifest partly as the hypertensive disorders of pregnancy and abruption or infarction of the placenta, occurs more commonly in women with obesity, chronic hypertension, diabetes mellitus, and dyslipidemia-each a major feature of the metabolic syndrome. However, the relationship between the metabolic syndrome and the future risk of PD or fetal demise is unknown. We completed a retrospective cohort study of 1.03 million women who had a first documented delivery in the province of Ontario between 1990 and 2002. Using linked administrative databases, we categorized women as having zero, one, two, or three to four features of the metabolic syndrome up to 24 months before their index delivery hospitalization. Women were considered to have placental dysfunction if they had a diagnosis of preeclampsia, gestational hypertension, placental abruption, or placental infarction during their first hospitalization for delivery in the period of study. At the time of delivery, 75 380 women (7.3%) were diagnosed as having PD. There was a progressive increase in the risk of PD in women with one (adjusted odds ratio [OR] 3.1; 95% confidence interval [CI] 3.0-3.1), two (OR 5.5; 95% CI 5.2-5.8), or three to four...Continue Reading

Citations

Feb 16, 2007·Epidemiology·Joel G RayMarian J Vermeulen
May 19, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·J G Ray, M L Urquia
Mar 27, 2013·Hypertension·Jan H W VeerbeekArie Franx
Jan 30, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A A Baschat
Feb 23, 2008·Anesthesiology·Hema S BagryFranco Carli
Mar 8, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·E StekkingerM E A Spaanderman
Jul 16, 2014·PloS One·Joel G RayMarian J Vermeulen
Feb 22, 2008·PPAR Research·Fritz WieserRobert N Taylor
Mar 12, 2010·Journal of Human Hypertension·Q LeiJ M Niu
Dec 4, 2008·Human Reproduction·H M SalihuA K Mbah
Jun 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Muktar H AliyuHamisu M Salihu
Dec 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·T B EilertsenS M Carlsen
Mar 21, 2009·Archives of Gynecology and Obstetrics·Banu DaneAhmet Cetin
Dec 25, 2012·Obstetrics and Gynecology·Ralph R ScholtenMarc E A Spaanderman
Jul 8, 2009·Orvosi hetilap·Boldizsár HorváthJózsef Bódis
Feb 27, 2013·Metabolic Syndrome and Related Disorders·Boldizsar HorvathJozsef Bodis
Aug 7, 2014·Current Hypertension Reports·Dawn C Scantlebury, Sharonne N Hayes
Mar 8, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·S Al-ObaidlyC Maxwell
Jan 19, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Eva StekkingerMarc E A Spaanderman
Oct 15, 2008·Placenta·R P WebsterL Myatt

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