Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease

Kidney & Blood Pressure Research
Maria Pietrzak-NowackaKazimierz Ciechanowski

Abstract

The aim of this work was to compare the prevalence of the metabolic syndrome (MS) and its components between a group of autosomal-dominant polycystic kidney disease (ADPKD) patients with normal kidney function and no prior diagnosis of diabetes and healthy controls. Forty-nine patients with ADPKD (age 35.9 +/- 11.1 years) with serum creatinine <1.35 mg/dl and 50 healthy controls (36.7 +/- 9.2 years) were enrolled for the study. Physical examination, basic laboratory measurements and oral glucose tolerance test were performed in all subjects. In the group of ADPKD patients, when compared to controls, the following values were significantly higher: waist-to-hip ratio (0.84 +/- 0.09 vs. 0.81 +/- 0.10, p = 0.046), systolic blood pressure (133.9 +/- 19.8 vs. 122.2 +/- 14.9 mm Hg, p = 0.0023), diastolic blood pressure (92.9 +/- 12.4 vs. 82.9 +/- 9.3 mm Hg, p < 0.0001), fasting glycemia (91.6 +/- 10.5 vs. 84.5 +/- 9.2 mg/dl, p = 0.04), and HbA(1C) (5.41 +/- 0.35 vs. 5.28 +/- 0.33%, p = 0.06, borderline significance). Adult Treatment Panel III criteria of MS were fulfilled by 14% of patients and 14% of controls, while International Diabetes Federation criteria were fulfilled by 22% of patients and 20% of controls, without any significa...Continue Reading

Citations

Dec 31, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Berenice ReedRobert W Schrier
Oct 6, 2012·American Journal of Nephrology·Imed HelalRobert W Schrier
Jan 1, 2016·Seminars in Nephrology·Katrina L CampbellAllison Tong
Jun 2, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert M HawsMartin A Turman
Feb 14, 2017·Journal of Translational Internal Medicine·Bennur EsenAhmet Engin Atay
May 28, 2019·Clinical and Experimental Nephrology·Ismail KocyigitJonas Axelsson
Apr 24, 2015·American Journal of Physiology. Renal Physiology·Kelli M SasP Darwin Bell

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