Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42

Oxidative Medicine and Cellular Longevity
Alfonso DiazGuadalupe Muñoz-Arenas

Abstract

An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of Aβ1-42 into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with Aβ1-42 show a major deterioration in the cognitive process. This event could be explained by the increment in the oxidative stress in both cases studied (MS and Aβ1-42): together, the hippocampus and temporal cortex produce an enhancer effect. In the same way, we observed an increment in interleukin-1β, TNF-α, and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and Aβ1-42. We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD. We propose that metabolic theory is important to explain the apparition of cognitive...Continue Reading

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Citations

Oct 17, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jacqueline SalasThierry A G M Huisman
Nov 27, 2019·Journal of Molecular Neuroscience : MN·Eliezer JosephMartha Cecilia Rosales-Hernández
Oct 26, 2018·International Journal of Molecular Sciences·Andrea TumminiaLucia Frittitta
Aug 14, 2020·Biological Trace Element Research·Cristhian Neftaly Sánchez-SolísSamuel Treviño

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Methods Mentioned

BETA
Assay
ELISA
sandwich immunoassay

Software Mentioned

Image Pro Premier

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