Metabolic syndrome impact on cardiac autonomic modulation and exercise capacity in obese adults

Autonomic Neuroscience : Basic & Clinical
Lívia Pinheiro CarvalhoAudrey Borghi-Silva

Abstract

Obesity is often associated with increased risk of cardiometabolic morbidities and mortality. However, evidence shows that some obese individuals are more likely to develop such risk factors early in life, including those with Metabolic Syndrome (MetS). Whether the presence of MetS in obese people impairs cardiac autonomic modulation (CAM) remains to be investigated. Cross-sectional study. Sixty-six subjects were classified as normal-weight (NW, n = 24) or obese (BMI ≥ 30 kg·m-2): metabolically healthy (MHO, n = 19) vs unhealthy (MUHO, n = 23: NCEP/ATPIII-MetS criteria). Body composition (bioimpedance), metabolic (glucose-insulin/lipid) and inflammatory profiles were determined. Linear and nonlinear heart rate variability (HRV) indices were computed at rest and during the submaximal six-minute step test (6MST). Blood pressure (BP) and metabolic and ventilatory variables were assessed (oxygen uptake, VO2; carbon dioxide production, VCO2; minute ventilation, VE) during the 6MST and the maximal cardiopulmonary exercise testing (CPX). All groups reached the same 6MST intensity (VO2 ~ 80% and HR ~ 87% of CPX peak values). Both obese groups, independently of MetS, presented higher BP and lower maximal VO2 than NW. However, HRV differ...Continue Reading

Citations

Aug 29, 2020·Research Quarterly for Exercise and Sport·André Rodrigues Lourenço DiasGisela Arsa
May 28, 2019·Frontiers in Physiology·Martin H LundqvistJan W Eriksson
Jan 6, 2021·Journal of Hypertension·Nour-Mounira Z BakkarSouha A Fares

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