Metabolic syndrome in patients with bipolar disorder: comparison with major depressive disorder and non-psychiatric controls

Journal of Psychosomatic Research
Barbora SilarovaAnnet T Spijker

Abstract

We aimed to investigate the prevalence of the metabolic syndrome (MetS) and its individual components in subjects with bipolar disorder (BD) compared to those with major depressive disorder (MDD) and non-psychiatric controls. We examined 2431 participants (mean age 44.3±13.0, 66.1% female), of whom 241 had BD; 1648 had MDD; and 542 were non-psychiatric controls. The MetS was ascertained according to NCEP ATP III criteria. Multivariable analyses were adjusted for age, sex, ethnicity, level of education, smoking status and severity of depressive symptoms, and in the case of BD subjects, also for psychotropic medication use. Subjects with BD had a significantly higher prevalence of MetS when compared to subjects with MDD and non-psychiatric controls (28.4% vs. 20.2% and 16.5%, respectively, p<0.001), also when adjusted for sociodemographic and lifestyle factors (OR 1.52, 95% CI: 1.09-2.12, p=0.02 compared to MDD; OR 1.79, 95% CI: 1.20-2.67, p=0.005 compared to non-psychiatric controls). The differences between BD subjects with controls could partly be ascribed to a higher mean waist circumference (91.0 cm vs. 88.8, respectively, p=0.03). In stratified analysis, the differences in the prevalence of MetS between patients with BD and...Continue Reading

References

May 1, 1986·Psychiatry Research·A J RushC Burns
May 1, 1996·Psychological Medicine·A J RushM H Trivedi
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Aug 2, 2003·Biological Psychiatry·Karen E JoyntChristopher M O'Connor
Jan 30, 2004·Recent Progress in Hormone Research·Elisabeth F C van Rossum, Steven W J Lamberts
May 26, 2005·JAMA : the Journal of the American Medical Association·David J Kupfer
Jul 28, 2006·Psychiatric Services : a Journal of the American Psychiatric Association·Roger S McIntyreSidney H Kennedy
Aug 8, 2006·The Journal of Clinical Psychiatry·Valerie Taylor, Glenda MacQueen
Feb 6, 2009·Journal of Affective Disorders·Hui Hua ChangRu Band Lu
Aug 20, 2009·Bipolar Disorders·Cynthia CalkinMartin Alda
Nov 17, 2009·Current Psychiatry Reports·Dylan P MurrayJess G Fiedorowicz
Nov 17, 2009·Journal of Clinical Psychopharmacology·Franca CentorrinoJane Chang
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Nianhong GuanTingjuan Wu
Jan 25, 2011·Psychosomatic Medicine·Floriana S LuppinoBrenda W J H Penninx
Apr 19, 2011·Journal of Affective Disorders·Brenda W J H PenninxAartjan T F Beekman
Nov 11, 2011·CNS Neuroscience & Therapeutics·Karla M de AlmeidaBeny Lafer
Nov 20, 2012·Indian Journal of Psychological Medicine·Sandeep GroverParmanand Kulhara
Mar 23, 2013·The New England Journal of Medicine·Gail L DaumitLawrence J Appel
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond

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Citations

Dec 13, 2017·Journal of Clinical Psychopharmacology·John J Mooney, Roscoe O Brady
Aug 24, 2018·Psychiatry Investigation·Ather Muneer, Rana Mazommil
Jul 18, 2018·European Archives of Psychiatry and Clinical Neuroscience·Sven SpeerforckG Schomerus
Sep 24, 2019·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisMichael Berk

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