Metabolic syndrome increases oxidative stress but does not influence disability and short-time outcome in acute ischemic stroke patients

Metabolic Brain Disease
Andréa Name Colado SimãoEdna Maria Vissoci Reiche

Abstract

Oxidative stress has been implicated in the pathophysiology of cardiovascular disease and MetS and it may be one of molecular mechanisms involved in stroke. The aims of the present study were to verify differences in oxidative stress markers in acute ischemic stroke patients with and without MetS and to verify whether MetS influences disability and short time outcome of the patients. 148 patients with acute ischemic stroke were divided in two groups: with MetS (n = 92) and without MetS (n = 56). The modified Rankin Scale (mRS) was used for measuring the functional disability after 3-month follow-up. The study assessed the metabolic profile and oxidative stress markers. Stroke patients with MetS had higher levels of lipid hydroperoxides (p < 0.0001) and advanced oxidation protein products (AOPP, p = 0.0302) than those without MetS. Hydroperoxides were directly and independently associated with MetS (OR: 1.000, 95 % IC = 1.000-1.000, p = 0.005). Linear regression demonstrated that AOPP levels (R(2) = 0.281, p < 0.0001) and oxidative stress index (OSI, R(2) = 0.223, p < 0.0001) were directly associated with triglycerides levels and hydroperoxides levels was also directly associated with glucose levels (R(2) = 0.080, p = 0.013. The...Continue Reading

References

Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·R Bonita, R Beaglehole
Jan 1, 1994·Methods in Enzymology·A Z Reznick, L Packer
Nov 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·M RepettoS Llesuy
Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
Aug 6, 2000·Stroke; a Journal of Cerebral Circulation·M M El Kossi, M M Zakhary
Oct 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S KalmijnL J Launer
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·K UchinoS C Cramer
Dec 26, 2001·Diabetes Research and Clinical Practice·K U Lee
Sep 27, 2002·QJM : Monthly Journal of the Association of Physicians·S E GariballaA J Sinclair
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Hideki UrakawaYukihiko Adachi
Feb 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M GrundyUNKNOWN American Heart Association
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Kristine YaffeAnne B Newman
Jul 5, 2005·Free Radical Biology & Medicine·Margarita L Alexandrova, Petyo G Bochev
Aug 6, 2005·Stroke; a Journal of Cerebral Circulation·Maarten UyttenboogaartGert-Jan Luijckx
Sep 6, 2005·Free Radical Biology & Medicine·Antonio CherubiniPatrizia Mecocci
Aug 19, 2006·Molecular Nutrition & Food Research·Katarína SebekováMarica Krajcovicová-Kudlácková
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi FujitaMichio Shimabukuro
Jan 26, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M F CasadoR Cecchini
Jan 10, 2009·Stroke; a Journal of Cerebral Circulation·Terence J QuinnKennedy R Lees
Sep 15, 2009·Journal of Atherosclerosis and Thrombosis·Takahito KondoKan Kageyama
Feb 27, 2010·Stroke; a Journal of Cerebral Circulation·Carmen DomínguezJoan Montaner
Sep 25, 2010·Journal of the American College of Cardiology·Salvatore MottilloMark J Eisenberg
Jan 27, 2011·Molecular Neurodegeneration·Trent M WoodruffThiruma V Arumugam
Apr 20, 2011·Circulation·Michael MillerUNKNOWN Council on the Kidney in Cardiovascular Disease
Feb 9, 2012·Expert Opinion on Therapeutic Targets·Isaias Dichi, Andrea Name Colado Simão
Jul 4, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Suchat HanchaiphiboolkulMaiyadhaj Samsen
Dec 4, 2012·Neurochemistry International·Silvia ManzaneroThiruma V Arumugam
Dec 21, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Baidarbhi ChakrabortySarita Agarwal
Mar 1, 2013·Cerebrovascular Diseases·Erwin ChiqueteCarlos Cantú-Brito
Feb 20, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Michael F OsbornJun Zhang
Jun 25, 2014·Journal of Endocrinological Investigation·E Zurawska-PłaksejA Piwowar
Jul 27, 2014·Metabolic Brain Disease·Johnathan de Sousa ParreiraEdna Maria Vissoci Reiche

❮ Previous
Next ❯

Citations

Aug 31, 2016·Molecular Medicine Reports·Zhiyou CaiGuanghui Chen
Jun 24, 2017·The Neurologist·Yi ChenZunyu Ke
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Grzegorz K JakubiakNatalia Pawlas
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yangang ChengMiaorong Pei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.