PMID: 18209894Jan 23, 2008Paper

Metabolic syndrome, its phenotypes, and insulin resistance by HOMA-IR

Arquivos brasileiros de endocrinologia e metabologia
Ernesto P de OliveiraMirabeau Levi A de Souza

Abstract

The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR > was higher in individuals with the MS (2.8+/-1.6 vs. 1.8+/-1.4) (p < 0.001). HOMA-IR >or= 2.5 allied good specificity and sensitivity levels for the association of MS and IR. Hyperglycemia, hypertrigliceridemia, and abdominal obesity, the MS components best related to IR, were statistically associated with HOMA-IR > 2.5, but not hypertension neither low HDL-c. The demonstration that some of MS phenotypes or associated abnormalities were more predictive for IR could point out to the possibility of the use of the index as a marker of the presence of IR associated to MS.

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Citations

Jul 18, 2015·BioMed Research International·Mónica Vázquez-Del MercadoRosa-Elena Navarro-Hernández
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May 24, 2018·Archives of Endocrinology and Metabolism·Nayara Rampazzo MorelliIsaias Dichi
Oct 8, 2020·Arquivos De Gastroenterologia·Lohanna Strauhs-NitschClaudia Alexandre Pontes Ivantes

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