Metabolic targeting can improve the efficiency of brain tumor biopsies.

Seminars in Oncology
Maikal Villena MartínAna María García Vicente

Abstract

Brain tumors comprise a heterogeneous group of diseases, featuring different biology, prognosis, and treatment. The most known forms are malignant gliomas and metastases. Brain biopsy is a recognized technique in the management of intracranial space-occupying lesions and tumors in particular. Tumor heterogeneity of malignant brain lesions has been described and can lead to significant sampling errors in stereotactic biopsy. Different methods have been used to perform biopsies, including biopsy guided by CT or RMI, echoguided or stereotactic. The choice of the target with the help of PET and MRI with spectroscopy allows one to identify metabolically more active areas of the tumor, and in this way reduce the rate of negative results.

Citations

Nov 6, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Louis Burt NaborsSusan D Darlow
Jul 19, 2021·European Journal of Radiology·Fulvio ZaccagnaFerdia A Gallagher

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