Metabolic Traits in Cutaneous Melanoma

Frontiers in Oncology
Monica Neagu

Abstract

Tumor microenvironment is a network of complex cellular and molecular systems where cells will gain specific phenotypes and specific functions that would drive tumorigenesis. In skin cancers, tumor microenvironment is characterized by tumor infiltrating immune cells that sustain immune suppression, mainly lymphocytes. Melanoma cellular heterogeneity can be described on genetic, proteomic, transcriptomic and metabolomic levels. Melanoma cells display a metabolic reprogramming triggered by both genetic alterations and adaptation to a microenvironment that lacks nutrients and oxygen supply. Tumor cells present clear metabolic adaptations and identifying deregulated glycolysis pathway could offer new therapy targets. Moreover, the immune cells (T lymphocytes, macrophages, NK cells, neutrophils and so on) that infiltrate melanoma tumors have metabolic particularities that, upon interaction within tumor microenvironment, would favor tumorigenesis. Analyzing both tumor cell metabolism and the metabolic outline of immune cells can offer innovative insights in new therapy targets and cancer therapeutical approaches. In addition to already approved immune- and targeted therapy in melanoma, approaching metabolic check-points could improve...Continue Reading

References

Jun 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christopher A KlebanoffNicholas P Restifo
Oct 18, 2005·Acta Oncologica·Liselotte DahlgrenBoel K Ragnarsson-Olding
Oct 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ann E Walts, Shikha Bose
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanne Krogh JensenHans von der Maase
Feb 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Silke KuphalAnja-Katrin Bosserhoff
Jun 24, 2010·Trends in Biochemical Sciences·David R Wise, Craig B Thompson
Oct 23, 2010·Molecular Cell·Amar J MajmundarM Celeste Simon
Mar 2, 2011·The American Journal of Pathology·Tatsuhiro ShibataNaoya Yamazaki
Mar 24, 2011·Cancer Research·Alyssa D Gregory, A McGarry Houghton
Aug 2, 2011·Nature Genetics·Jason W LocasaleMatthew G Vander Heiden
Sep 1, 2011·Nature Reviews. Drug Discovery·Matthew G Vander Heiden
Sep 10, 2011·Frontiers in Pharmacology·Paolo E PorporatoPierre Sonveaux
Oct 12, 2011·Annual Review of Cell and Developmental Biology·Sophia Y Lunt, Matthew G Vander Heiden
Oct 15, 2011·The Journal of Biological Chemistry·David A ScottJeffrey W Smith
Oct 10, 2012·Molecular Cancer·Jonhan HoStergios J Moschos
Jan 10, 2013·Annual Review of Immunology·Nancie J MacIverJeffrey C Rathmell
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J O'DayAxel Hauschild
Jun 12, 2013·The Journal of Experimental Medicine·Rikke B HolmgaardJames P Allison
Jul 5, 2013·Nature Reviews. Cancer·Jason W Locasale
Oct 5, 2013·The Journal of Clinical Investigation·Madhusudhanan SukumarLuca Gattinoni
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ping YuanBin Zheng
Jan 8, 2014·Nature Reviews. Endocrinology·Ida Pernicova, Márta Korbonits
Jul 6, 2014·Cancer Research·Deepak MittalMark J Smyth
Nov 22, 2014·Science·Jennifer A Lo, David E Fisher
Dec 24, 2014·Nature Reviews. Immunology·Edward J Pearce, Bart Everts
Mar 6, 2015·Science Translational Medicine·Stephen M HatfieldMichail V Sitkovsky
Apr 4, 2015·Journal of Immunoassay & Immunochemistry·Monica NeaguCaterina Longo
Aug 12, 2015·The Journal of Experimental Medicine·Michael D BuckErika L Pearce
Dec 24, 2015·The Journal of Experimental Medicine·Luke A J O'Neill, Edward J Pearce
Jan 1, 2016·Cancer Research·Shari Pilon-ThomasRobert J Gillies
May 21, 2016·Frontiers in Immunology·Megan M TuAndrew P Makrigiannis
Jun 9, 2016·Oncogene·B I RatnikovZ A Ronai

❮ Previous
Next ❯

Citations

Aug 29, 2020·Journal of Immunology Research·Corina Daniela EneSimona Roxana Georgescu
Oct 23, 2020·Journal of Immunoassay & Immunochemistry·Monica Neagu
Feb 7, 2021·Molecular Cancer·Longzheng XiaQianjin Liao
May 4, 2021·Frontiers in Oncology·Chandra K SinghNihal Ahmad

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.