Metabolically healthy obese subjects are at risk of fatty liver but not of pre-clinical atherosclerosis

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Ki-Chul SungChristopher D Byrne

Abstract

Whether obesity increases risk of cardiovascular disease (CVD) and fatty liver because of the co-existence of other risk factors is uncertain. We investigated odds ratios (ORs) for: a) a measure of pre-clinical atherosclerosis and b) fatty liver, in metabolically healthy obese (MHO) subjects, metabolically abnormal obese (MAO) subjects and metabolically abnormal non obese subjects (MANO), using a metabolically healthy non obese (MHNO) group as the reference. 14,384 South Koreans from an occupational cohort underwent cardiac computed tomography (CT) estimation of CAC score, liver ultrasound determination of fatty liver, and measurement of cardiovascular risk factors. Pre-clinical atherosclerosis was defined by a CAC score >0. We used logistic regression to determine ORs for CAC >0, and fatty liver in MHO, MAO and MANO subjects (reference group MHNO). There was no increase in OR for CAC score >0 (OR = 0.93, [95% CIs 0.67,1.31], p = 0.68), in the MHO group, whereas there was an increase in the ORs for CAC score >0 in the MAO, and MANO groups (OR = 1.64 [95% CI 1.36,1.98], p < 0.001) and (OR = 1.38 [95% CI 1.17,1.64], p < 0.001), respectively. In contrast, for fatty liver, there was an increase in OR in each group (OR = 3.63 [95% C...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Jan 4, 1986·British Medical Journal·S H SaverymuttuJ D Maxwell
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Philip GreenlandRobert C Detrano
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Dec 24, 2004·The New England Journal of Medicine·Frank B HuJoAnn E Manson
Jan 27, 2005·Diabetes & Metabolism·A D KarelisR Rabasa-Lhoret
May 11, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Annie C St-PierreBenoît Lamarche
Jun 25, 2005·Obesity Research·Gianluca IacobellisFrida Leonetti
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·James B MeigsRalph B D'Agostino
Feb 14, 2007·The American Journal of Medicine·Richard N BergmanMarilyn Ader
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Feb 27, 2009·Clinical Science·Christopher D ByrneMohamed H Ahmed
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Dec 29, 2010·The American Journal of Medicine·Eun-Jung RheeKi-Chul Sung
Jan 12, 2012·Gut·Philip Noel NewsomeUNKNOWN British Transplant Society
Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Mark Hamer, Emmanuel Stamatakis
Apr 24, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Stefano BallestriPaola Loria
Jul 10, 2012·The Journal of Clinical Endocrinology and Metabolism·Jean-Pierre Després
Sep 6, 2012·European Heart Journal·Francisco B OrtegaSteven N Blair

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Citations

Nov 1, 2015·International Journal of Environmental Research and Public Health·Ruizhi ZhengMaode Lai
Feb 3, 2016·Current HIV/AIDS Reports·Kristine M Erlandson, Jordan E Lake
Feb 3, 2016·The International Journal of Cardiovascular Imaging·Nobuo TomizawaSunao Nakamura
Feb 26, 2015·Metabolic Syndrome and Related Disorders·Giovanni Targher, Christopher D Byrne
May 18, 2016·The American Journal of Gastroenterology·Yoosoo ChangSeungho Ryu
Apr 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ji Yeon KimKyu Yong Choi
May 31, 2016·International Journal of Environmental Research and Public Health·Shasha YuYingxian Sun
Aug 12, 2016·Metabolic Syndrome and Related Disorders·Sasa DusanovSerena Tonstad
Oct 11, 2016·Annals of the New York Academy of Sciences·Catherine M Phillips
Jun 13, 2017·The Korean Journal of Internal Medicine·Chang Hee JungKee-Ho Song
Oct 26, 2018·Alimentary Pharmacology & Therapeutics·Javier AmpueroUNKNOWN HEPAmet Registry
Oct 23, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Daniel J CuthbertsonMarkus Juonala
Sep 1, 2016·Expert Review of Endocrinology & Metabolism·J A Bell, M Hamer
Dec 7, 2018·Frontiers in Endocrinology·João Sérgio NevesPaula Freitas
Jan 25, 2019·International Journal of Endocrinology·Hye Soo ChungKyung Mook Choi
Jun 30, 2016·Nature Reviews. Gastroenterology & Hepatology·Giovanni Targher, Christopher D Byrne
May 12, 2021·Journal of Gastroenterology and Hepatology·Tsung-Po ChenKuen-Cheh Yang
Jul 26, 2021·Clinics and Research in Hepatology and Gastroenterology·Helda TutunchiAlireza Ostadrahimi

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