Metabolically healthy obesity and lipids may be protective factors for pathological changes of alzheimer's disease in cognitively normal adults.

Journal of Neurochemistry
Shu-Juan HuangJin-Tai Yu


The associations between obesity and Alzheimer's disease (AD) at different ages have been debated. Recent evidence implied the protective effects of metabolically healthy obesity on AD. We hypothesized that obesity and lipids could mitigate the detrimental impacts of AD pathological changes among metabolically healthy individuals in late life. In this study, a total of 604 metabolically healthy participants with normal cognition were included from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database. Multiple linear regression models were used to test the associations of body mass index (BMI) or lipids with cerebrospinal fluid (CSF) biomarkers after adjustment for age, gender, education, and Apolipoprotein E-ɛ4 (APOE-ɛ4). The results showed the lower CSF levels of total tau protein (t-tau: p = .0048) and phosphorylated tau protein (p-tau: p = .0035) in obese participants than in non-obese participants, even after correcting for covariates. Moreover in late life, higher BMI was associated with decreased CSF t-tau (β: -0.15, p = .0145) and p-tau (β: -0.17, p = .0052). As for lipids, higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were associated with decreased CSF t-tau (TC: β: ...Continue Reading


May 23, 2001·JAMA : the Journal of the American Medical Association·Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Nov 2, 2002·Journal of the American Geriatrics Society·Fati NourhashémiBruno Vellas
Apr 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Antony D KarelisRemi Rabasa-Lhoret
May 3, 2005·BMJ : British Medical Journal·Rachel A WhitmerKristine Yaffe
Sep 27, 2005·Journal of the American Geriatrics Society·Takuya WatanabeTakashi Iguchi
Sep 28, 2005·Neurology·A S BuchmanDavid A Bennett
Oct 12, 2005·Archives of Neurology·Miia KivipeltoAulikki Nissinen
Jan 9, 2007·Neurobiology of Aging·Jelena DjordjevicHoward Chertkow
Nov 22, 2007·Journal of the American Geriatrics Society·Anna Rita AttiLaura Fratiglioni
Aug 7, 2008·The Journal of Clinical Endocrinology and Metabolism·Carlos A Aguilar-SalinasFrancisco J Gómez-Pérez
Aug 19, 2008·Journal of Clinical Nursing·Chia-Chi Chang, Beverly L Roberts
Dec 20, 2008·Journal of the American Geriatrics Society·Anna K DahlSirkka-Liisa Kivelä
Jan 27, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nancy A West, Mary N Haan
Mar 11, 2009·Archives of Neurology·Annette L FitzpatrickJosé A Luchsinger
Jun 12, 2009·Journal of the American Geriatrics Society·Wael K Al-DelaimyElizabeth Barrett-Connor
Jan 4, 2012·Annals of the New York Academy of Sciences·Edward B Lee
Jan 19, 2012·International Journal of Alzheimer's Disease·Dayne Beccano-Kelly, Jenni Harvey
Feb 21, 2013·Annals of Neurology·David S KnopmanRonald C Petersen
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Mar 5, 2015·Journal of Alzheimer's Disease : JAD·Hyemin JangSang Won Seo
Sep 2, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anders WimoMartin Prince
Feb 26, 2019·The Journal of Clinical Endocrinology and Metabolism·Ji-Yeon LeeYong-Ho Lee
Sep 14, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Dinesh Kumar BarupalAlzheimer Disease Metabolomics Consortium
Dec 4, 2019·Aging·Ling-Zhi MaAlzheimer's Disease Neuroimaging Initiative
Jul 14, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Wei XuJin-Tai Yu

Related Concepts

Alzheimer's Disease
Apolipoprotein E
Biological Markers
Genetic Carriers
Cerebrospinal Fluid
LDL Cholesterol Lipoproteins

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.