Metabolically Healthy Obesity.

Endocrine Reviews
Matthias Blüher

Abstract

Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities, mainly in those individuals who develop cardiovascular diseases, type 2 diabetes, osteoarthritis, and cancer. However, there is a large variation in the individual risk to developing obesity-associated comorbid diseases that cannot simply be explained by the extent of adiposity. Observations that a proportion of individuals with obesity have a significantly lower risk for cardiometabolic abnormalities led to the concept of metabolically healthy obesity (MHO). Although there is no clear definition, normal glucose and lipid metabolism parameters-in addition to the absence of hypertension-usually serve as criteria to diagnose MHO. Biological mechanisms underlying MHO lower amounts of ectopic fat (visceral and liver), and higher leg fat deposition, expandability of subcutaneous adipose tissue, preserved insulin sensitivity, and beta-cell function as well as better cardiorespiratory fitness compared to unhealthy obesity. Whereas the absence of metabolic abnormalities may reduce the risk of type 2 diabetes and cardiovascular diseases in metabolically healthy individuals compared to unhealthy individuals with obesity, it is still higher in comp...Continue Reading

References

May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 6, 2001·Metabolism: Clinical and Experimental·E A Sims
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Kevin R FontaineDavid B Allison
Jul 2, 2004·EMBO Reports·Jackie Leach Scully
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·James B MeigsRalph B D'Agostino
Aug 25, 2007·The Journal of Clinical Investigation·Ja-Young KimPhilipp E Scherer
May 28, 2008·Diabetologia·A D KarelisR Rabasa-Lhoret
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Sep 17, 2008·Biochemical Society Transactions·Chong Yew Tan, Antonio Vidal-Puig
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Feb 4, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A M Sharma, R F Kushner
Apr 10, 2009·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M Blüher
Jul 15, 2009·Nature Chemical Biology·Jonathan W DayMatthias H Tschöp
Nov 17, 2009·Current Opinion in Lipidology·Matthias Blüher
Jun 24, 2010·American Journal of Physiology. Endocrinology and Metabolism·Nora KlötingMatthias Blüher
Jun 25, 2010·Diabetes Care·Peter M Janiszewski, Robert Ross
Jul 16, 2010·European Journal of Clinical Nutrition·S VelhoP Marques-Vidal
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Apr 30, 2011·Journal of Diabetes Science and Technology·Loganathan GeethaViswanathan Mohan
Aug 30, 2011·Lancet·Boyd A SwinburnSteven L Gortmaker
Jan 27, 2012·The Journal of Clinical Hypertension·Rabia CherqaouiOtelio S Randall
Sep 6, 2012·European Heart Journal·Francisco B OrtegaSteven N Blair
Jan 11, 2013·Journal of Obesity·C M DurwardS M Nickols-Richardson
Feb 19, 2013·Obesity·Xanthia F SamaropoulosLynne E Wagenknecht
Mar 16, 2013·Diabetes Care·Sarah L AppletonUNKNOWN North West Adelaide Health Study Team
Apr 6, 2013·The Journal of Clinical Endocrinology and Metabolism·Federico SoriguerGemma Rojo-Martínez
Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Matthias Blüher
Sep 10, 2013·Cell Metabolism·Gregory GaichDavid E Moller
Dec 4, 2013·Annals of Internal Medicine·Caroline K KramerRavi Retnakaran
Feb 28, 2014·Diabetes Care·Rhiannon L PrinceGeoff D C Ball

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Citations

Jun 2, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Chien-Ju LinTzu Lin Yeh
Aug 21, 2020·Endocrinology and Metabolism·Norbert Stefan
Aug 31, 2020·World Journal of Diabetes·Fernando Pazos
Aug 5, 2020·Journal of Dairy Science·Morteza H GhaffariHelga Sauerwein
Sep 3, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Arij MulhemMatthias Blüher
Dec 18, 2020·Frontiers in Human Neuroscience·Maria PoesselAnnette Horstmann
Dec 2, 2020·Cardiovascular Research·John E HallJussara M do Carmo
Dec 23, 2020·Immunity & Ageing : I & a·Julia Sbierski-KindDominik Spira
Aug 22, 2020·Canadian Journal of Physiology and Pharmacology·Aleksandra ArsicDanijela Ristic Medic
Jan 23, 2021·Nature Reviews. Endocrinology·Norbert StefanMatthias B Schulze
Dec 16, 2020·Animals : an Open Access Journal From MDPI·Margherita MaranesiFrancesca Mercati
Dec 19, 2020·Antioxidants·Marta Gómez de CedrónAna Ramírez de Molina
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Karl Z NadolskyW Timothy Garvey
Dec 1, 2020·Frontiers in Endocrinology·Claudio ChiesaCristina Cadenas-Sanchez
Feb 28, 2021·Molecular and Cellular Biochemistry·Yingjuan LiuYunliang Guo
Feb 25, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Victor L PicoloDenis B Rosemberg
Mar 5, 2021·The World Journal of Men's Health·Patrizia D'Amelio
Mar 9, 2021·Frontiers in Nutrition·Alistaire D RuggieroKylie Kavanagh
Apr 4, 2021·International Journal of Environmental Research and Public Health·Wei-Lun WenSzu-Chia Chen
Apr 6, 2021·Diabetes & Metabolism Journal·Ji A Seo
Apr 15, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Licy L Yanes Cardozo, Damian G Romero
Apr 29, 2021·Scientific Reports·Sheng-Huei WangGen-Min Lin
Apr 30, 2021·European Journal of Clinical Nutrition·Patricia CorralesGema Medina-Gómez
Apr 30, 2021·BMC Endocrine Disorders·Daniel Elías-LópezUNKNOWN Metabolic Syndrome Study Group
Apr 24, 2021·World Journal of Diabetes·Magdalena Paczkowska-Abdulsalam, Adam Kretowski
May 5, 2021·Chemico-biological Interactions·Melania Iara FunkRomina María Uranga
May 7, 2021·Molecular and Cellular Endocrinology·Pamela A Nono Nankam, Matthias Blüher
May 3, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Spyridon N KarrasKalliopi Kotsa
Apr 17, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Omar Ramos-LopezUNKNOWN Collaborators: Rodrigo San-Cristobal and Maria P. Portillo
May 25, 2021·World Journal of Methodology·Cornelius J FernandezJoseph M Pappachan

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Methods Mentioned

BETA
gastric bypass
transgenic
Pharmacotherapies
adding
pharmcotherapies
pharmacotherapy

Software Mentioned

BioShare

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