PMID: 11310422Apr 20, 2001Paper

Metabolism 2000: the emperor needs new clothes

The Proceedings of the Nutrition Society
V R Young, A M Ajami

Abstract

Metabolism is one of the corner stones of nutritional science. As biology enters the post-genomic era and with functional genomics beginning to takeoff, we anticipate that the study of metabolism will play an increasingly important role in helping to link advances made via the reductionist paradigm, that has been so successful in molecular and cellular biology, with those emerging from observational studies in animals and human subjects. A reconstructive metabolically-focused approach offers a timely paradigm for enhancing the elegance of nutritional science. Here we give particular attention to the use of tracers as phenotyping tools and discuss the application of our metaprobe concepts with respect to some novel features of metabolism, including 'underground metabolism', 'metabolic hijacking', 'catalytic promiscuity' and 'moonlighting proteins'. The opportunities for enhancing the study of metabolism by new and emerging technologies, and the importance of the interdisciplinary research enterprise are also touched upon. We conclude that: (1) the metaprobe concepts and approach, discussed herein, potentially yield a quantitative physiological (metabolic) phenotype against which to elaborate partial or focused genotypes; (2) phy...Continue Reading

References

Dec 1, 1992·Nutrition Reviews·V R Young
May 1, 1992·Metabolism: Clinical and Experimental·B MarescauP P De Deyn
Jan 1, 1991·Metabolism: Clinical and Experimental·B Caballero, R J Wurtman
Jan 1, 1988·Journal of Inherited Metabolic Disease·T KatoC Hayakawa
Jan 1, 1989·Journal of Inherited Metabolic Disease·T KatoN Mizutani
Aug 1, 1989·Metabolism: Clinical and Experimental·J Katz
Aug 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·P J McNamaraT L Hayden
Feb 1, 1970·Behaviour Research and Therapy·K Freund, R Costell
Jan 1, 1993·Journal of Inherited Metabolic Disease·T Kato, M Sano
Nov 1, 1995·The American Journal of Clinical Nutrition·Y M YuV R Young
May 1, 1995·Metabolism: Clinical and Experimental·B MarescauC Mahler
May 1, 1995·Metabolism: Clinical and Experimental·Y M YuJ F Burke
Nov 23, 1994·JAMA : the Journal of the American Medical Association·S B RobertsV R Young
Sep 1, 1993·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·T J OverendM S Lefcoe
Jan 1, 1995·Annual Review of Nutrition·J C Waterlow
Jan 1, 1995·Pharmacology & Therapeutics·G PowisJ Oblong
Jul 1, 1996·The American Journal of Clinical Nutrition·Y M YuV R Young
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·L CastilloV R Young
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·O E RooyackersK S Nair
Jan 1, 1997·The Journal of Clinical Investigation·E StroesT Rabelink
Oct 2, 1997·The New England Journal of Medicine·R Weindruch, R S Sohal
Oct 10, 1997·The American Journal of Clinical Nutrition·J E Morley
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W Dröge, E Holm
Jan 20, 1998·Biochimica Et Biophysica Acta·D F Cunningham, B O'Connor
May 16, 1998·The Biochemical Journal·S Ogbourne, T M Antalis
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Apr 29, 1998·Metabolism: Clinical and Experimental·P H BarrettD M Foster
Jun 13, 1998·The Journal of Clinical Investigation·E VolpiR R Wolfe
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R D'Ari, J Casadesús
Jul 29, 1998·Chemico-biological Interactions·M E Anderson
Aug 8, 1998·Journal of Neuroscience Methods·T KohnoK Ishikawa
Nov 21, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·K J MelansonS B Roberts
Jan 6, 1999·Archives of Pharmacal Research·J H RyuY N Han
Jan 23, 1999·Nature Genetics·E S Lander
Feb 13, 1999·Science·P J MagistrettiR G Shulman
Mar 24, 1999·Trends in Biochemical Sciences·C J Jeffery
Apr 1, 1999·Chemistry & Biology·P J O'Brien, D Herschlag

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Citations

Feb 13, 2008·Omics : a Journal of Integrative Biology·Lise LévesqueBéatrice Godard
Nov 26, 2009·The International Journal of Biochemistry & Cell Biology·Petr JezekRodrigue Rossignol
Mar 9, 2006·Molecular and Biochemical Parasitology·Naji KhayathColette Dissous
Feb 11, 2003·Critical Care Medicine·Zvi ArgamanLeticia Castillo
Feb 26, 2010·Medical Anthropology·Ian Whitmarsh
Dec 20, 2013·BMC Sports Science, Medicine and Rehabilitation·Mathias WolfrumRomuald Lepers
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yong-Ming YuVernon R Young

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