Metabolism and cancer: the circadian clock connection.

Nature Reviews. Cancer
Saurabh Sahar, Paolo Sassone-Corsi

Abstract

Circadian rhythms govern a remarkable variety of metabolic and physiological functions. Accumulating epidemiological and genetic evidence indicates that the disruption of circadian rhythms might be directly linked to cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of the cell cycle, and alterations in clock function could lead to aberrant cellular proliferation. In addition, connections between the circadian clock and cellular metabolism have been identified that are regulated by chromatin remodelling. This suggests that abnormal metabolism in cancer could also be a consequence of a disrupted circadian clock. Therefore, a comprehensive understanding of the molecular links that connect the circadian clock to the cell cycle and metabolism could provide therapeutic benefit against certain human neoplasias.

References

Jan 1, 1980·Gastroenterologia Japonica·H TsubouchiS Hashimoto
May 16, 1997·Cell·D P KingJ S Takahashi
Dec 18, 1998·Neuron·M J ZylkaS M Reppert
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M H VitaternaA Sancar
Jul 7, 2000·British Journal of Cancer·A Compagni, G Christofori
Sep 20, 2000·Genes & Development·M E Ewen
Nov 23, 2000·Nature·R A DePinho
Dec 2, 2000·Nature Neuroscience·C CrosioP Sassone-Corsi
Sep 5, 2001·Nature Reviews. Genetics·M W Young, S A Kay
Oct 18, 2001·Journal of the National Cancer Institute·E S SchernhammerG A Colditz
Oct 24, 2001·Cell·H VaziriR A Weinberg
Apr 19, 2002·Chronobiology International·Minoru KobayashiWilliam J M Hrushesky
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
Nov 28, 2002·Journal of Lipid Research·Eric RaspéBart Staels
Dec 17, 2002·Nature·Jean-Pierre EtchegaraySteven M Reppert
Dec 20, 2002·Cancer·Katherine A McGlynnRobert E Tarone
Jan 1, 2003·Cell·Ueli Schibler, Paolo Sassone-Corsi
Jun 28, 2003·Nature Immunology·Mark M Davis
Jul 5, 2003·Science·Carol A DudleySteven L McKnight
Jul 17, 2003·The Journal of Biological Chemistry·Katsutaka OishiNorio Ishida
Aug 2, 2003·Nature Reviews. Neuroscience·Michael H HastingsElizabeth S Maywood
Aug 23, 2003·Science·Takuya MatsuoHitoshi Okamura
Feb 24, 1956·Science·O WARBURG
Oct 18, 2003·Science·Jessica W BarnesMartha U Gillette
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert R KleveczDouglas B Murray
Mar 17, 2004·Molecular Cell·Haim Y CohenDavid A Sinclair

❮ Previous
Next ❯

Citations

Dec 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zsuzsanna LengyelAndrás Dávid Nagy
Jun 8, 2012·Biochemistry·Take MatsuyamaYoshinori Shichida
Oct 27, 2010·Nature Neuroscience·Selma Masri, Paolo Sassone-Corsi
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jin Hyup Lee, Aziz Sancar
Jun 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew R Ramsey, Leif W Ellisen
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chiara StringariEnrico Gratton
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shobhan GaddameedhiAziz Sancar
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sankar Mitra
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wendy W Hwang-VersluesWen-Hwa Lee
Feb 8, 2011·The Journal of Biological Chemistry·Molly S Bray, Martin E Young
Dec 4, 2012·Antioxidants & Redox Signaling·Melissa WilkingNihal Ahmad
Jul 4, 2012·Nucleic Acids Research·Yukimasa TakedaAnton M Jetten
Mar 1, 2011·Occupational Medicine·X-S WangR C Travis
Mar 23, 2010·Current Opinion in Rheumatology·Astrid JüngelSteffen Gay
May 3, 2012·Genes & Development·Chi V Dang
Oct 13, 2010·Molecular and Cellular Biology·Fumiyuki HatanakaToru Takumi
Jul 16, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anastasia RenziGianfranco Alpini
Nov 1, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yi WangXinfu Guan
Jan 16, 2013·Chemotherapy Research and Practice·Katrin Sak
Sep 11, 2012·BMC Molecular Biology·Xiaochao TanXiaozhong Peng
Apr 1, 2010·Journal of Circadian Rhythms·Sobia Rana, Saqib Mahmood
Dec 22, 2011·Endocrinology·Paolo Sassone-Corsi
Nov 5, 2010·Journal of Cell Science·Marina Maria Bellet, Paolo Sassone-Corsi
Feb 22, 2012·Annals of Surgical Oncology·Xiaoliang WangZhihai Peng
Apr 17, 2014·PLoS Biology·Ron C AnafiJohn B Hogenesch
Dec 24, 2011·PLoS Computational Biology·Angela RelógioHanspeter Herzel
Jun 14, 2012·PLoS Computational Biology·Claude Gérard, Albert Goldbeter
May 31, 2014·PLoS Genetics·Angela RelógioChristine Sers
Nov 3, 2012·The Tohoku Journal of Experimental Medicine·Soisungwan Satarug, Michael R Moore
Dec 15, 2010·Endocrine-related Cancer·Catherine OrySylvie Chevillard
Dec 12, 2012·OncoTargets and Therapy·Rui ChenHong Tang
Jan 29, 2014·Neuroscience and Biobehavioral Reviews·Erin L ZelinskiRobert J McDonald
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jin Hyup Lee, Aziz Sancar
Jul 19, 2011·Journal of Aging Research·D McGuinnessP G Shiels
Sep 23, 2014·Fungal Genetics and Biology : FG & B·Judit ZámborszkyChristian I Hong

❮ Previous
Next ❯

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