Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
J M SandersL T Burka

Abstract

The metabolism and disposition of (14)C-labelled 2,2',4,4'-tetrabromodiphenyl ether (BDE47) were investigated in F344 rats and B6C3F1 mice. Approximately 75-85% of 1 micromol BDE47 kg(-1) was absorbed following oral administration to either rats or mice. Sex and species differences were observed in tissue distribution and excretion of BDE47-derived radioactivity. Absorption and distribution of (14)C to major tissues were dose-proportional in male rats from 0.1 to 1,000 micromol kg(-1). BDE47-derived radioactivity increased in all rat and mouse tissues examined following repeated daily doses of 1 micromol kg(-1). Accumulation of (14)C in tissues of mice was less than in corresponding rat tissues. Glutathione conjugates of BDE47 were excreted in rat bile. A glucuronide and a sulfate conjugate of 2,4-dibromophenol were detected in the urine of BDE47-treated rats. BDE47 appears to induce its own metabolism. Increased formation of reactive metabolites over time may correlate with toxicological effects in BDE47-treated rodents.

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Citations

Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Amy Lavin Williams, John M DeSesso
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik PacyniakGrace L Guo
Nov 17, 2006·Environmental Health Perspectives·Linda S Birnbaum, Elaine A Cohen Hubal
Aug 23, 2008·Endocrine Journal·Yukiko KawashiroChisato Mori
Oct 2, 2012·Neurotoxicology and Teratology·Claire M KoenigRobert F Berman
Sep 3, 2011·Toxicology and Applied Pharmacology·Erik PacyniakGrace L Guo
Sep 9, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·June K Dunnick, Abraham Nyska
Jul 11, 2006·Toxicology and Applied Pharmacology·Rocío F CantónMartin van den Berg
Nov 4, 2009·Toxicology and Applied Pharmacology·Claude EmondLinda S Birnbaum
Feb 6, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mi-Yeon ShinSungkyoon Kim
Dec 13, 2019·Toxicologic Pathology·June K DunnickArun Kumar R Pandiri
Sep 15, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M SandersL T Burka
Jun 14, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L-J ChenL T Burka
Oct 16, 2008·Environmental Science & Technology·Janice K HuweLinda S Birnbaum
Aug 5, 2010·Journal of Agricultural and Food Chemistry·Heldur HakkDrew Rutherford

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