Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats

Scientific Reports
Liye WangZong-Hui Yuan

Abstract

Aditoprim (ADP) is a newly developed antibacterial agent in veterinary medicine. The metabolism and disposition of ADP in swine, broilers, carp and rats were investigated by using a radio tracer method combined with a radioactivity detector and a liquid chromatography/ion trap/time-of-flight mass spectrometry. After a single oral administration, more than 94% of the dose was recovered within 14 d in the four species. The urine excretion was dominant in swine and rats, making up 78% of the dose. N-monodesmethyl-ADP, N-didesmethyl-ADP, and 10 new metabolites were characterized. These metabolites were biotransformed from the process of demethylation, α-hydroxylation, N-oxidation, and NH2-glucuronidation. After an oral dose for 7 d, ADP-derived radioactivity was widely distributed in tissues, and high concentrations were especially observed in bile, liver, kidney, lung, and spleen. The radioactivity in the liver was eliminated much more slowly than in other tissues, with a half-life of 4.26, 3.38, 6.69, and 5.21 d in swine, broilers, carp, and rats, respectively. ADP, N-monodesmethyl-ADP, and N-didesmethyl-ADP were the major metabolites in edible tissues. Notably, ADP was detected with the highest concentration and the longest dura...Continue Reading

References

May 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·R L von FellenbergW F Rehm
Dec 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·J L Riond, J E Riviere
Jan 1, 1987·Zentralblatt für Veterinärmedizin. Reihe A·J C JordanB Ludwig
Jun 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·N W KnoppertA S van Miert
Feb 1, 1988·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R L Then, M Keller
Nov 1, 1987·Pharmacology & Toxicology·P NielsenW J Xia
Jun 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·K HaenniW F Rehm
Nov 1, 1973·The Journal of Infectious Diseases·C W SigelC A Nichol
Nov 1, 1984·Acta Pharmacologica Et Toxicologica·N Gyrd-HansenF Rasmussen
May 1, 1995·Biopharmaceutics & Drug Disposition·M P IqbalN Mahboobali
Aug 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·A S van Miert
Mar 1, 1994·Biopharmaceutics & Drug Disposition·M P IqbalK N Khawaja
Nov 1, 1995·Biopharmaceutics & Drug Disposition·M P IqbalA A Zaidi
Dec 20, 2005·Biochemical Pharmacology·Stephen HawserKhalid Islam
Mar 6, 2010·Handbook of Experimental Pharmacology·Pierre-Louis ToutainAlain Bousquet-Mélou
Jun 8, 2011·Future Medicinal Chemistry·Leposava Antonovic, Marilyn Martinez
Feb 7, 2012·Chemical Biology & Drug Design·Ramadoss VijayarajPratim Kumar Chattaraj
Jul 19, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ronald E WhiteFrancis L S Tse
Jul 8, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hui WangXianhui Huang
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas H HutchinsonColin H Walker
Feb 11, 2015·Journal of Applied Toxicology : JAT·Xu WangZonghui Yuan
Mar 3, 2015·Analytical Biochemistry·Zhishui LiHeguang Huang

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Methods Mentioned

BETA
column chromatography
dissecting

Software Mentioned

WinNonlin

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