PMID: 6538540Mar 1, 1984Paper

Metabolism and distribution of 3,4-epithiobutanenitrile in the rat

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
E R BrockerA von Däniken

Abstract

The metabolism and distribution of [2-14C]- and 35S-labelled 3,4-epithiobutanenitrile (4ETN), a thiirane occurring naturally in cruciferous vegetables, was studied in the rat. A dose of c. 11 mg 4ETN/kg body weight was rapidly transformed into water-soluble compounds and was mainly excreted in the urine, irrespective of the route of administration (oral or ip). The main metabolite in the urine was identified by gas chromatography-mass spectrometry as a mercapturic acid derivative. Low residual radioactivity demonstrated in organs 72 hr after administration was consistent with an earlier report that the thiirane may function as a weak biological alkylating agent.

Citations

Jan 1, 1988·International Archives of Occupational and Environmental Health·L Aringer, V Lidums
Feb 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A WalligM J Fettman
Feb 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A WalligC C Willhite
Nov 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L VanSteenhouseD H Gould
Aug 8, 2015·Molecular Nutrition & Food Research·Franziska S HanschenEvelyn Lamy
Aug 29, 2014·Angewandte Chemie·Franziska S HanschenSascha Rohn
Apr 1, 2014·Journal of Agricultural and Food Chemistry·Mark G CollettBrian A Tapper
May 29, 2018·Molecular Nutrition & Food Research·Arjan Narbad, John Trevor Rossiter
Jan 25, 2017·Current Pharmaceutical Design·Edoardo CapuanoTeresa Oliviero

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