Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses

Journal of Toxicology and Environmental Health
J M MathewsA R Jeffcoat

Abstract

The disposition of [14C]bromodichloromethane (BDCM) was studied in male Fischer rats after single oral doses of 1, 10, 32, or 100 mg/kg and 10-d repeat oral dosing of 10 or 100 mg/kg/d. Methods were developed to quantitate exhaled 14CO and 14CO2. Bromodichloromethane was extensively (approximately 80-90%) metabolized within 24 h postdosing with approximately 70-80% of the administered dose appearing as 14CO2 and approximately 3-5% as 14CO. Urinary and fecal elimination were low, accounting for 4-5% and 1-3% of the dose, respectively. Oral administration of BDCM at a level of 10 mg/kg/d for 10 d did not result in the bioaccumulation or altered disposition of the test chemical, but during the course of the repeat 100 mg/kg/d dosing the rate of production of 14CO2 increased, suggesting that this dose of BDCM induced its own metabolism. Persistence of radiolabeled residues in tissues collected 24 h after single-dose administration was low (3-4% of dose), with the most marked accumulation (1-3% of dose) in liver. Kidney tissue, particularly the cortical region, also contained significant concentrations of residues.

References

Nov 21, 1977·Biochemical and Biophysical Research Communications·D MansuyJ P Leroux
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Oct 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J R BucherJ D Prejean
Nov 1, 1986·Bulletin of Environmental Contamination and Toxicology·F L MinkJ Rickabaugh

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Citations

Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·Annie St-PierreRobert Tardif
Dec 1, 1993·Environmental Health Perspectives·M M LipskyC O'Connell
Sep 8, 2012·Inhalation Toxicology·Minerva Nájera-MartínezArmando Vega-López
Nov 24, 2011·Regulatory Toxicology and Pharmacology : RTP·Sangeeta BanerjiThomas Höfer
Jul 28, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Teresa L LeavensRex A Pegram

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