Metabolism and excretion of orally and intraperitoneally administered gallium arsenide in the hamster

Toxicology
H YamauchiY Yamamura

Abstract

This study deals with the metabolism of gallium arsenide (GaAs). GaAs was shown to be soluble in various media. Since this compound could dissolve in aqueous solvents, in vivo dissolution was investigated. Hamsters were used to study the dissolution and subsequent pharmacokinetics of any liberated arsenic species. The fecal and urinary excretion data following oral and intraperitoneal administration showed that GaAs, when administered orally, is mostly excreted in the feces but poorly in the urine, and that the compound, when administered intraperitoneally, is poorly excreted in both the feces and urine. Analysis of tissues for arsenic levels yielded concentrations in the ppb range, which further verified this fact. Most interesting was the fact that dimethylarsinic acid (DMAA) and methylarsonic acid (MAA) along with inorganic arsenic were found in the urine and tissues. GaAs was shown to dissolve in vivo and the released arsenic species were metabolized as other inorganic arsenics were found in the urine and tissues. GaAs was shown to dissolve in vivo and the released arsenic species were metabolized as other inorganic arsenic containing compounds. The low solubility and poor oral absorption may make this compound less toxic t...Continue Reading

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Citations

Jun 4, 2013·Environmental Geochemistry and Health·Violet DiacomanolisJack C Ng
Jul 28, 2004·Toxicology and Applied Pharmacology·Akiyo Tanaka
Mar 18, 2003·International Immunopharmacology·Timothy A Gondre-LewisKathleen L McCoy
Jul 13, 2007·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xuemei WeiYiping Du
Aug 1, 1991·Toxicology and Applied Pharmacology·E E SikorskiA E Munson
Aug 1, 1991·Toxicology and Applied Pharmacology·E E SikorskiA E Munson
May 28, 2013·Critical Reviews in Toxicology·Ernst M BomhardSamuel M Cohen
Aug 26, 1998·Toxicology and Applied Pharmacology·R E Caffrey-Nolan, K L McCoy
Dec 3, 2020·Toxicology and Applied Pharmacology·Hiroshi Yamauchi, Ayako Takata

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