PMID: 3768390Oct 24, 1986Paper

Metabolism and function of platelet-activating factor in fetal rabbit lung development

Biochimica Et Biophysica Acta
D R HoffmanJ M Johnston

Abstract

Previously, platelet-activating factor (PAF, PAF-acether, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) had been identified in association with a lamellar-body-enriched fraction of human amniotic fluid obtained from women in labor. In consideration of the fact that fetal lung is the source of lamellar bodies, we have investigated the capacity of the developing lung to synthesize PAF. The specific activity of the PAF biosynthetic enzyme, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine: acetyl-CoA acetyltransferase, increased from 116 pmol/min per mg protein in day 21 fetal rabbit lung to 332 pmol/min per mg protein by day 31. Although this enzymatic activity in fetal kidney also increased, it never reached the level found in lung. In contrast, the actyltransferase activity decreased by 80% in fetal liver between days 21 and 31. The acetyltransferase activity in lung was primarily localized in the microsomal fraction (105 000 X g pellet); however a significant proportion of the activity was found in the 18 000 X g pellet. The specific activity of acetyltransferase in adult alveolar type II rat pneumonocytes was significantly higher than that of adult rat lung or rat alveolar macrophages, suggesting that type II cells make a significan...Continue Reading

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Citations

Apr 3, 1993·Lancet·M S Caplan
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N MakiJ M Johnston
Sep 1, 1992·American Journal of Obstetrics and Gynecology·B L TaborA H Jobe
Mar 28, 2008·Reproduction in Domestic Animals = Zuchthygiene·U Tiemann
Sep 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R D EvansD H Williamson
Mar 14, 2000·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·J C Voudouris, M M Kuftinec
Nov 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J SugataniK Saito
Jul 1, 1991·Experimental Lung Research·J R BourbonJ M Johnston
Jan 1, 1986·American Journal of Hematology·D J Carty, A R Gear
Feb 3, 2000·Journal of Biomaterials Applications·R Banerjee, R R Puniyani
Jan 1, 1996·Progress in Lipid Research·R A FrenkelJ M Johnston
Sep 23, 1988·Biochimica Et Biophysica Acta·M J AngleJ M Johnston
Apr 3, 1993·Lancet·F R MoyaJ M Johnston
Oct 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P V Peplow, D P Mikhailidis

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